Description

(1S)-3,4-Dihydro-1-Phenyl-2(1H)-Isoquinolinecarboxylic Acid 2,5-Dioxo-1-Pyrrolidinyl Ester is a high-purity, advanced pharmaceutical intermediate designed for critical synthetic applications. This compound serves as a key activated ester building block, enabling efficient amide bond formation under mild conditions, which is essential for constructing complex molecular architectures. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), particularly within medicinal chemistry and process R&D.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of complex drug candidates and active pharmaceutical ingredients (APIs).
• Peptidomimetic Synthesis: Used in the preparation of peptide analogs and constrained scaffolds for drug discovery programs.
• Medicinal Chemistry Research: Enables the efficient coupling of carboxylic acid-containing fragments to amines in library synthesis and lead optimization.
• Bioconjugation: Applicable in the field of bioconjugation for attaching small molecules to proteins or other biomolecules.
• Process Chemistry Development: Serves as a reagent in scaling up synthetic routes from laboratory to pilot plant scale.
• Academic Research: Employed in universities and research institutes for methodological studies in organic synthesis and heterocyclic chemistry.

Basic Information

Product Name	(1S)-3,4-Dihydro-1-Phenyl-2(1H)-Isoquinolinecarboxylic Acid 2,5-Dioxo-1-Pyrrolidinyl Ester
CAS No.	1534326-80-1
Molecular Formula	C20H16N2O4
Molecular Weight	348.35 g/mol
Synonyms	(1S)-1-Phenyl-1,2,3,4-tetrahydroisoquinoline-2-carboxylic acid 2,5-dioxopyrrolidin-1-yl ester; (S)-N-(2,5-Dioxopyrrolidin-1-yl)-1-phenyl-1,2,3,4-tetrahydroisoquinoline-2-carboxamide; 1-Phenyl-1,2,3,4-tetrahydroisoquinoline-2-carbonyloxysuccinimide (S-enantiomer); (S)-1-Phenyl-1,2,3,4-tetrahydroisoquinoline-2-carboxylic acid N-hydroxysuccinimide ester; NSC 870064; Activated ester of (S)-1-Phenyl-THIQ-2-carboxylic acid; Succinimidyl (S)-1-phenyl-1,2,3,4-tetrahydroisoquinoline-2-carboxylate
EINECS	Contact for details

Quality Control

Our (1S)-3,4-Dihydro-1-Phenyl-2(1H)-Isoquinolinecarboxylic Acid 2,5-Dioxo-1-Pyrrolidinyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.