Description

Tos-Peg7-Ch2Co2T-Butyl Ester is a specialized bifunctional PEG derivative featuring a tosylate (Tos) leaving group and a protected carboxylic acid (t-butyl ester) terminus, connected by a heptaethylene glycol (PEG7) spacer. This molecular architecture makes it a highly versatile intermediate for the controlled synthesis of functionalized polymers, bioconjugates, and advanced drug delivery systems. It is particularly valuable for researchers and manufacturers in the pharmaceutical, biotechnology, and advanced materials sectors who require precise, water-soluble linkers for attaching bioactive molecules or creating stimuli-responsive materials.

Application

• Pharmaceutical Linker Chemistry: Serves as a key building block for creating antibody-drug conjugates (ADCs), peptide-drug conjugates, and other targeted therapeutics, where the tosylate group enables selective coupling to nucleophiles.
• Polymer Functionalization: Used to introduce protected carboxyl groups into polymer backbones (e.g., PEGylation) for subsequent deprotection and further modification, enabling the creation of smart hydrogels and functional coatings.
• Prodrug Synthesis: Facilitates the development of prodrugs by linking active pharmaceutical ingredients (APIs) via the acid-labile t-butyl ester, allowing for controlled release in specific physiological environments.
• Bioconjugation and Labeling: Acts as a heterobifunctional crosslinker for attaching dyes, probes, or proteins to surfaces or other biomolecules, leveraging its orthogonal reactive sites.
• Materials Science Research: Employed in the synthesis of novel non-ionic surfactants, dispersants, and surface-modifying agents due to its amphiphilic PEG chain.

Basic Information

Product Name	Tos-Peg7-Ch2Co2T-Butyl Ester
CAS No.	1530777-90-2
Molecular Formula	C30H60O13S
Molecular Weight	660.86 g/mol
Synonyms	2,5,8,11,14,17,20-Heptaoxadocosan-22-oic acid, 1-[(4-methylphenyl)sulfonyl]-, 1,1-dimethylethyl ester; Tosyl-PEG7-t-butyl ester; Tos-PEG7-COOtBu; Tosylate-PEG7-acid t-butyl ester; 4-Methylbenzenesulfonic acid PEG7 t-butyl ester; tert-Butyl 2,5,8,11,14,17,20-heptaoxa-22-[(tosyl)oxy]docosanoate; PEG7 Tosylate t-Butyl Ester; Heterobifunctional PEG derivative, Tos-PEG7-COOtBu
EINECS	Contact for details

Quality Control

Our Tos-Peg7-Ch2Co2T-Butyl Ester is manufactured under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (NMR, IR, and Mass Spectrometry), to ensure it meets the high standards required for research and pharmaceutical applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. Due to its hygroscopic nature, the container should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Assay	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.