Description

Long Trebler Phosphoramidite is a specialized phosphoramidite monomer, a critical building block in the automated synthesis of oligonucleotides. Its value lies in enabling the precise and efficient incorporation of unique modifications into DNA or RNA strands, which is essential for advanced research and therapeutic development. This high-purity reagent is primarily needed by biotechnology and pharmaceutical companies engaged in antisense drug discovery, diagnostic probe development, and fundamental nucleic acid research.

Application

• Oligonucleotide Synthesis: As a key monomer in solid-phase phosphoramidite chemistry for automated DNA/RNA synthesizers.
• Antisense & siRNA Therapeutics: For the production of chemically modified oligonucleotides used in gene silencing and targeted therapeutic applications.
• Diagnostic Probe Development: In the manufacture of labeled probes for PCR, FISH, and microarray technologies requiring specific functionalization.
• Structural Studies: For introducing site-specific modifications to study nucleic acid structure, function, and protein interactions.
• Aptamer Development: In the synthesis of SELEX libraries to discover high-affinity binding molecules for diagnostic and therapeutic use.
• Next-Generation Sequencing (NGS): For preparing specialized adapters or primers with unique chemical handles.

Basic Information

Item	Details
Product Name	Long Trebler Phosphoramidite
CAS No.	1516489-83-0
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Long Trebler Phosphoramidite Monomer; 5'-Long Trebler Phosphoramidite; Long-Trebler-CE Phosphoramidite; Long Trebler Amidite; Long Trebler modifier phosphoramidite; Trityl-Long Trebler Phosphoramidite; DMT-Long Trebler Phosphoramidite
EINECS	Contact for details

Quality Control

Our Long Trebler Phosphoramidite is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity suitable for sensitive oligonucleotide synthesis. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and moisture content. We adhere to relevant industry standards and our quality protocols are designed to support applications in GMP-grade therapeutic oligonucleotide production.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (argon or nitrogen) in a dry, moisture-free environment. This product is hygroscopic (moisture-sensitive) and easily oxidized; prolonged exposure to air or moisture will significantly degrade performance. Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid or foam
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Moisture Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.