Description

Bis-Peg2-Endo-Bcn CAS NO 1476737-97-9 is a specialized bifunctional polyethylene glycol (PEG) linker featuring an endo-BCN (bicyclo[6.1.0]nonyne) group, designed for advanced bioconjugation and click chemistry applications. This compound is critical for creating stable, site-specific linkages between biomolecules, nanoparticles, and surfaces under mild, bio-orthogonal conditions. It is essential for researchers and manufacturers in pharmaceutical development, proteomics, and diagnostic assay platforms who require precise and efficient conjugation strategies.

Application

• Bioconjugation and Antibody-Drug Conjugate (ADC) Development: For the site-specific attachment of cytotoxic payloads, fluorophores, or other functional molecules to antibodies and proteins.
• Proteomics and Biomarker Discovery: Used to label and enrich proteins or peptides for mass spectrometry analysis and interaction studies.
• Diagnostic Reagent Manufacturing: Enables the stable conjugation of detection molecules (e.g., enzymes, dyes) to antibodies or antigens in ELISA and lateral flow assays.
• Nanoparticle and Liposome Functionalization: Facilitates the surface modification of drug delivery carriers with targeting ligands or stealth PEG layers.
• Materials Science and Surface Chemistry: Employed to create bio-functionalized surfaces for biosensors, microarrays, and cell culture substrates.
• Chemical Biology and Probe Development: Serves as a key reagent for synthesizing activity-based probes to study enzyme function and metabolic pathways.

Basic Information

Product Name	Bis-Peg2-Endo-Bcn
CAS No.	1476737-97-9
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	1,11-Bis((endo-BCN)oxy)-3,6,9-trioxaundecane; BCN-PEG2-BCN; endo-BCN-PEG2-endo-BCN; Bis(endo-BCN-PEG2); Bifunctional PEG2 BCN linker; BCN-PEG2 crosslinker; endo-Bicyclo[6.1.0]nonyne-PEG2-endo-Bicyclo[6.1.0]nonyne; BCN-PEG2-BCN NHS ester precursor
EINECS	Contact for details

Quality Control

Our Bis-Peg2-Endo-Bcn is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistent performance for sensitive bioconjugation workflows. Certificates of Analysis (COA) with detailed chromatographic data are available upon request to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive) and light-sensitive (store away from light). Allow the vial to warm to room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid or oil
Identification (HPLC/MS)	Complies
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.