Description

Tos-Peg13-Tos CAS NO 1456708-45-4 is a high-purity, heterobifunctional polyethylene glycol (PEG) linker featuring terminal tosylate (Tos) groups. This compound is a critical reagent for the controlled synthesis and functionalization of biomolecules, nanoparticles, and polymers, enabling precise cross-linking and conjugation. It is essential for researchers and manufacturers in the pharmaceutical, bioconjugation, and advanced materials sectors who require reliable, well-defined PEG spacers to enhance solubility, reduce immunogenicity, and modify physicochemical properties.

Application

• Bioconjugation and Protein Modification: Acts as a versatile linker for attaching drugs, dyes, or targeting ligands to antibodies, peptides, and proteins.
• Polymer and Dendrimer Synthesis: Serves as a building block or chain extender in the creation of functionalized PEG-based polymers and dendritic structures.
• Nanoparticle Surface Functionalization: Used to modify the surface of liposomes, quantum dots, and other nanoparticles to improve stability, biocompatibility, and targeting capability.
• Prodrug Development: Facilitates the design of PEGylated prodrugs for controlled drug release and enhanced pharmacokinetic profiles.
• Diagnostic Reagent Preparation: Employed in the synthesis of contrast agents and molecular probes for imaging applications.
• Hydrogel and Biomaterial Fabrication: Utilized as a cross-linking agent to create PEG-based hydrogels for tissue engineering and drug delivery systems.
• Solid-Phase Peptide Synthesis (SPPS): Functions as a soluble polymer support or as a component for introducing PEG chains into peptide sequences.
• Surface Chemistry and Sensor Development: Applied to create functionalized surfaces on chips and biosensors for specific molecular capture.

Basic Information

Product Name	Tos-Peg13-Tos
CAS No.	1456708-45-4
Molecular Formula	C34H62O17S2
Molecular Weight	806.96 g/mol
Synonyms	α,ω-Bis(tosylate) PEG13; 1,1'-[1,11-Dioxo-3,6,9-trioxa-2,10-diazadodecane-1,12-diyl]bis(4-methylbenzenesulfonate) (PEG13 analog); Bis(p-toluenesulfonate) PEG13; PEG-13 ditosylate; Ditosyl-PEG13; Heterobifunctional PEG13 ditosylate; 3,6,9,12,15,18,21,24,27,30,33-Undecaoxapentatriacontane-1,35-diyl bis(4-methylbenzenesulfonate); Tos-(OCH2CH2)13-Tos
EINECS	Contact for details

Quality Control

Our Tos-Peg13-Tos is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistent performance. We provide comprehensive Certificates of Analysis (COA) that include data for identity, assay, and impurity profiles. Our quality commitment aligns with the standards required for research and cGMP manufacturing applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive); keep the container tightly sealed in a desiccated environment to prevent degradation. Handle and store under an inert atmosphere (e.g., nitrogen or argon) for long-term stability.

Specification

Item	Specification
Appearance	White to off-white solid or viscous liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Purity (HPLC, Area%)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Functional Group Analysis	90-110% of theoretical

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.