Description

Tos-Peg4-Acid CAS NO 1453117-42-4 is a heterobifunctional polyethylene glycol (PEG) derivative featuring a tosyl (Tos) group at one terminus and a carboxylic acid (Acid) at the other, linked by a tetraethylene glycol (PEG4) spacer. This compound is a critical building block in bioconjugation and pharmaceutical development, enabling the controlled, sequential attachment of molecules. It is primarily utilized by researchers and manufacturers in the fields of biopharmaceuticals, diagnostics, and advanced material science for creating PEGylated therapeutics, cross-linked hydrogels, and functionalized surfaces.

Application

• Bioconjugation and Linker Chemistry: Serves as a versatile heterobifunctional crosslinker for attaching peptides, proteins, or other biomolecules to surfaces, nanoparticles, or drug payloads via orthogonal reactive groups.
• PEGylation Reagent: Used to introduce PEG chains onto drug molecules or proteins to enhance solubility, prolong circulation half-life, and reduce immunogenicity.
• Polymer and Material Science: Acts as a monomer or functional initiator for synthesizing tailored polymers, smart hydrogels, and biocompatible coatings with specific end-group functionality.
• Diagnostic Probe Synthesis: Facilitates the development of labeled probes and assay components for diagnostic applications, such as in ELISA or lateral flow tests.
• Antibody-Drug Conjugate (ADC) Development: Provides a valuable tool for constructing stable, cleavable, or non-cleavable linkers in ADC platforms.
• Surface Functionalization: Used to modify the surface properties of materials like gold nanoparticles, quantum dots, or chromatography resins for specific binding or stealth characteristics.
• Click Chemistry Precursor: The carboxylic acid group can be readily converted to an azide or alkyne for use in copper-catalyzed or strain-promoted azide-alkyne cycloaddition (SPAAC) reactions.
• Research and Development: A key intermediate in academic and industrial R&D for exploring new drug delivery systems and biomaterial interfaces.

Basic Information

Item	Details
Product Name	Tos-Peg4-Acid
CAS No.	1453117-42-4
Molecular Formula	C19H30O9S
Molecular Weight	434.50 g/mol
Synonyms	4-Methylbenzenesulfonic acid 2,5,8,11-tetraoxatridecan-13-oic acid ester; Tosyl-PEG4-acid; p-Toluenesulfonate PEG4 propionic acid; 17-Tosyl-3,6,9,12-tetraoxaheptadecanoic acid; 2,5,8,11-Tetraoxatridecan-13-oic acid, 1-(4-methylbenzenesulfonate); Tos-PEG4-COOH; Heterobifunctional PEG derivative Tos-PEG4-Acid; PEG4 spacer with Tosyl and Acid groups
EINECS	Contact for details

Quality Control

Our Tos-Peg4-Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for research and pharmaceutical applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Assay	≥ 97%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.