Description

Hs-Peg5-Ch2Ch2Cooh is a heterobifunctional polyethylene glycol (PEG) derivative featuring a thiol-reactive end group and a carboxylic acid terminus. This compound is engineered to serve as a versatile linker for bioconjugation, enabling the precise attachment of biomolecules, nanoparticles, or surfaces. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and advanced materials sectors for applications such as drug delivery system development, surface functionalization, and diagnostic assay enhancement.

Application

• Bioconjugation Linker: For site-specific coupling of peptides, proteins, or antibodies to other molecules, surfaces, or nanoparticles via its thiol and carboxylate reactive groups.
• Drug Delivery Systems: As a functional component in the synthesis of PEGylated drug conjugates, enhancing solubility, stability, and pharmacokinetic profiles of therapeutic agents.
• Surface Modification: For creating functionalized surfaces on biosensors, microarrays, or medical devices to improve biocompatibility and enable specific biomolecular capture.
• Cross-linking Agent: In the preparation of hydrogels or polymer networks for tissue engineering and controlled release applications.
• Diagnostic Reagent Synthesis: Used in the development of labeled probes and assay components for diagnostic and research purposes.
• Nanoparticle Functionalization: To attach targeting ligands or therapeutic payloads to gold, iron oxide, or polymeric nanoparticles.

Basic Information

Product Name	Hs-Peg5-Ch2Ch2Cooh
CAS No.	1449390-67-3
Molecular Formula	C18H34O9S
Molecular Weight	426.53 g/mol
Synonyms	HS-PEG5-COOH; Thiol-PEG5-acid; α-Thiol-ω-carboxy pentakis(ethylene glycol); 2,5,8,11,14-Pentaoxaheptadecane-17-thioic acid, 16-mercapto-; 16-Mercapto-2,5,8,11,14-pentaoxaheptadecane-17-thioic acid; Heterobifunctional PEG, HS-PEG5-AA; 3,6,9,12,15-Pentaoxaheptadecane-1,17-dithioic acid (isomer); PEG-based crosslinker, thiol and acid functionalized.
EINECS	Contact for details

Quality Control

Our Hs-Peg5-Ch2Ch2Cooh is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity verification, to ensure it meets the high standards required for research and bioconjugation applications. Certificates of Analysis (COA) with detailed specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., nitrogen or argon) due to its hygroscopic and easily oxidized nature. Allow the sealed container to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Molecular Weight (MS)	426.53 ± 2 g/mol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.