Description

Tfp-Peg2-Tfp CAS NO 1446282-27-4 is a heterobifunctional polyethylene glycol (PEG) crosslinker featuring two tetrafluorophenyl (TFP) ester reactive groups. This compound is specifically engineered for efficient and selective bioconjugation, enabling the stable coupling of biomolecules under mild aqueous conditions. It is an essential reagent for researchers and manufacturers in biopharmaceutical development, proteomics, and advanced materials science, where precise and reliable crosslinking is required.

Application

• Bioconjugation and Protein Modification: Used to crosslink proteins, peptides, antibodies, or enzymes with other biomolecules or solid surfaces via amine groups.
• Antibody-Drug Conjugate (ADC) Linker Development: Serves as a cleavable or non-cleavable linker platform for constructing ADCs, connecting cytotoxic payloads to targeting antibodies.
• PEGylation Reagent: Acts as a functionalized PEG spacer to modify therapeutic proteins, enhancing solubility, stability, and pharmacokinetic profiles.
• Surface Functionalization: Enables the covalent attachment of biomolecules to nanoparticles, biosensors, microarrays, and other material surfaces for diagnostic and research applications.
• Hydrogel and Biomaterial Synthesis: Utilized as a crosslinking agent in the creation of PEG-based hydrogels for tissue engineering and drug delivery systems.
• Diagnostic Assay Development: Facilitates the stable immobilization of capture antibodies or antigens on assay plates and beads in ELISA and other immunoassays.

Basic Information

Product Name	Tfp-Peg2-Tfp
CAS No.	1446282-27-4
Molecular Formula	C24H22F4O7
Molecular Weight	498.43 g/mol
Synonyms	1,11-Bis(2,3,5,6-tetrafluorophenoxy)-3,6,9-trioxaundecane; Tetrafluorophenyl-PEG2-tetrafluorophenyl ester; TFP-PEG2-TFP ester; Bis-TFP-PEG2; 2,2'-(Ethane-1,2-diylbis(oxy))bis(ethane-2,1-diyl) bis(2,3,5,6-tetrafluorobenzoate); TFP-PEG2-TFP; Heterobifunctional PEG crosslinker TFP-PEG2-TFP; TFP ester-PEG2-TFP ester
EINECS	Contact for details

Quality Control

Our Tfp-Peg2-Tfp is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure high purity and consistent performance for critical research and development applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment. We adhere to relevant industry standards for fine chemical and bioconjugation reagent production.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture absorption. For long-term storage, keep under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid or viscous liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.