Description

Mpeg2-Hydrazide CAS NO 1442104-10-0 is a specialized functionalized polyethylene glycol (PEG) derivative, where a hydrazide group is conjugated to a methoxy PEG (mPEG) chain of approximately 2,000 Daltons. This compound is engineered to serve as a critical linker and conjugation reagent in advanced bioconjugation and pharmaceutical formulation. It is primarily utilized by researchers and manufacturers in the pharmaceutical and biotechnology sectors who require precise and stable covalent attachment of biomolecules, such as proteins, peptides, or drug payloads, to PEG chains for enhanced therapeutic properties.

Application

• Bioconjugation Linker: For the site-specific covalent attachment of mPEG chains to carbonyl groups (aldehydes, ketones) present on proteins, antibodies, or other biomolecules.
• PEGylation Reagent: Used in the development of PEGylated therapeutics to improve drug solubility, prolong circulation half-life, and reduce immunogenicity.
• Drug Delivery Systems: As a functional component in the synthesis of prodrugs or targeted drug delivery conjugates, such as antibody-drug conjugates (ADCs).
• Surface Modification: For functionalizing nanoparticles, liposomes, or diagnostic agents with hydrophilic PEG chains to enhance biocompatibility and stealth properties.
• Cross-linking Agent: In the preparation of hydrogels, biomaterials, or affinity matrices where a stable hydrazone bond formation is desired.
• Diagnostic Reagent Synthesis: In the labeling of biomarkers or contrast agents for in vitro diagnostics or imaging applications.

Basic Information

Product Name	Mpeg2-Hydrazide
CAS No.	1442104-10-0
Molecular Formula	CnH2n+2O(n+1)·(C2H6N2O) (Representative for mPEG~2000 Hydrazide)
Molecular Weight	~2000 g/mol (Average Mn)
Synonyms	mPEG2000-Hydrazide; Methoxy Polyethylene Glycol 2000 Hydrazide; α-Methoxy-ω-hydrazido poly(ethylene glycol); PEG-Hydrazide (MW 2000); mPEG-HZ (2000); Poly(oxy-1,2-ethanediyl), α-methoxy-ω-hydrazino-; 2-[2-[2-(2-Methoxyethoxy)ethoxy]ethoxy]ethyl hydrazine (oligomer); Hydrazide-PEG-OMe (2000)
EINECS	Contact for details

Quality Control

Our Mpeg2-Hydrazide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure it meets high-purity standards suitable for research and pharmaceutical applications. A comprehensive Certificate of Analysis (COA) is provided, detailing parameters such as purity, molecular weight distribution, functional group substitution, and absence of critical impurities. We support compliance with relevant guidelines for pharmaceutical excipients.

Storage

Preserve in a tightly closed container, protected from light. Due to its hygroscopic (moisture-sensitive) nature, store under dry, inert conditions (e.g., nitrogen or argon atmosphere) at a controlled room temperature (15-25°C). For long-term stability, desiccants are recommended. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white waxy solid or powder
Identification (IR)	Conforms to structure
Average Molecular Weight (Mn)	1900 - 2100 Da
Polydispersity Index (PDI)	≤ 1.05
Assay (Hydrazide Content)	≥ 95%
Purity (HPLC)	≥ 98%
Methoxy Substitution	≥ 95%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.