Description

Cravatt Reagent CAS NO 1438416-21-7 is a specialized chemical compound designed for advanced chemical biology and proteomics research. This reagent is critical for enabling activity-based protein profiling (ABPP), a powerful technique for studying enzyme function and identifying drug targets in complex biological systems. It is an essential tool for researchers and pharmaceutical developers in the fields of drug discovery, chemical biology, and functional proteomics.

Application

• Activity-Based Protein Profiling (ABPP): As a core reagent for labeling and identifying active enzymes within native biological systems.
• Drug Discovery & Target Identification: Used to discover and validate novel enzyme targets for therapeutic intervention in disease pathways.
• Chemical Proteomics: Enables the global analysis of protein function and activity states in cells and tissues.
• Enzyme Inhibitor Screening: Serves as a key component in high-throughput screens for discovering potent and selective enzyme inhibitors.
• Mechanism of Action Studies: Employed to elucidate the biological mechanisms and off-target effects of drug candidates.
• Diagnostic Probe Development: Used in the design and synthesis of molecular probes for disease detection and imaging.

Basic Information

Product Name	Cravatt Reagent
CAS No.	1438416-21-7
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Activity-Based Probe (ABP) Core Structure; Chemical Proteomics Probe; ABPP Reagent; Sulfonate Ester Probe; Cravatt Lab Reagent; Proteome Profiling Reagent; Enzyme Activity Reporter; Reactive Chemical Tag
EINECS	Contact for details

Quality Control

Our Cravatt Reagent is manufactured under strict quality control protocols to ensure the high purity and batch-to-batch consistency required for sensitive research applications. Each lot is characterized using advanced analytical techniques, including NMR and mass spectrometry, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and stability is provided with every shipment to support your research documentation and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a desiccated environment to prevent degradation. For long-term stability, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.