Description

6-Hydroxy Chlorzoxazone-D2 is a deuterated isotopologue of the primary metabolite of the muscle relaxant chlorzoxazone, specifically labeled at key positions. This compound is of critical importance as a high-purity internal standard and reference material for quantitative bioanalytical methods, ensuring accuracy and reliability in pharmacokinetic and metabolic studies. It is primarily needed by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical testing facilities engaged in drug development, doping control, and forensic analysis.

Application

• Bioanalytical Internal Standard: Used as a deuterium-labeled internal standard in LC-MS/MS and GC-MS assays for the precise quantification of 6-hydroxy chlorzoxazone and chlorzoxazone in biological matrices like plasma, serum, and urine.
• Drug Metabolism Studies (DMPK): Essential for investigating the metabolic pathways, clearance rates, and bioavailability of the parent drug chlorzoxazone in preclinical and clinical research.
• Pharmaceutical Impurity Profiling: Serves as a certified reference standard to identify and quantify related substances and degradation products in active pharmaceutical ingredient (API) batches.
• Forensic and Doping Control Analysis: Employed as a calibrant in confirmatory methods for detecting chlorzoxazone and its metabolite in forensic toxicology and anti-doping programs.
• Stable Isotope Labeling Research: Used in mechanistic studies to trace metabolic fate using stable isotope techniques.

Basic Information

Product Name	6-Hydroxy Chlorzoxazone-D2
CAS No.	1432065-00-3
Molecular Formula	C7H3D2ClN2O3
Molecular Weight	202.61 g/mol (approximate)
Synonyms	6-Hydroxychlorzoxazone-D2; 5-Chloro-2(3H)-benzoxazolone-6-ol-D2; 5-Chloro-6-hydroxy-2-benzoxazolinone-D2; Chlorzoxazone Metabolite D2; 6-OH Chlorzoxazone-D2; Deuterated 6-Hydroxy Chlorzoxazone; [D2]-6-Hydroxychlorzoxazone; 6-Hydroxy-5-chlorobenzoxazol-2-one-D2
EINECS	Contact for details

Quality Control

Our 6-Hydroxy Chlorzoxazone-D2 is manufactured under controlled conditions to meet the exacting standards required for analytical reference materials. Each batch undergoes comprehensive characterization and purity verification using advanced techniques including NMR, HPLC, and mass spectrometry. We provide a comprehensive Certificate of Analysis (COA) detailing isotopic purity, chemical purity, and analytical results. Our quality system supports compliance with relevant guidelines for reference standards.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Purity (D2)	≥98.0 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.