Description

Ezetimibe-D4 -D-Glucuronide, >85% is a deuterated and glucuronidated metabolite analog of the cholesterol absorption inhibitor, Ezetimibe. This stable isotope-labeled compound is critical for ensuring the accuracy and reliability of quantitative bioanalytical methods in drug development and pharmacokinetic studies. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical testing facilities specializing in mass spectrometry.

Application

• Internal Standard for LC-MS/MS Analysis: Serves as a crucial quantitative reference standard for the precise measurement of Ezetimibe glucuronide metabolite levels in biological matrices such as plasma, serum, and urine.
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Enables accurate tracking of the absorption, distribution, metabolism, and excretion (ADME) profile of Ezetimibe in preclinical and clinical research.
• Bioanalytical Method Development and Validation: Used to develop, optimize, and validate robust, sensitive, and specific analytical assays compliant with FDA and ICH guidelines.
• Clinical Trial Support: Provides essential data integrity for pharmacokinetic and bioequivalence studies during clinical phases of drug development.
• High-Purity Reference Material: Acts as a certified reference material for calibrating instruments and ensuring quality control in analytical laboratories.

Basic Information

Product Name	Ezetimibe-D4 -D-Glucuronide, >85%
CAS No.	1426174-41-5
Molecular Formula	C38H45D4NO7
Molecular Weight	~ 655.8 g/mol
Synonyms	(3R,4S)-1-(4-Fluorophenyl)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-[(4-hydroxyphenyl)methyl]azetidin-2-one-D4 Glucuronide; Ezetimibe D4 Glucuronide; Ezetimibe Glucuronide-d4; Ezetimibe-D4 Glucuronide Metabolite; Ezetimibe Glucuronide (Deuterated); SCHEMBL21850231; 1-(4-Fluorophenyl)-3(R)-[3(S)-(4-fluorophenyl)-3-hydroxypropyl]-4(S)-(4-hydroxyphenyl)-2-azetidinone-D4 Glucuronide
EINECS	Contact for details

Quality Control

Our Ezetimibe-D4 -D-Glucuronide is manufactured under strict quality protocols to ensure high chemical purity and isotopic enrichment suitable for sensitive analytical applications. Each batch is characterized by advanced spectroscopic and chromatographic techniques, including NMR, HPLC, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, isotopic purity (D4), and impurity profile is provided to guarantee traceability and compliance with your research standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	> 85%
Isotopic Purity (D4)	> 98 atom % D
Water Content (KF)	< 2.0 %
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.