Description

Bis-Mal-Lysine-Peg4-Tfp Ester is a heterobifunctional crosslinking reagent featuring a lysine core with two maleimide groups and a tetrafluorophenyl (Tfp) ester. This compound is engineered for the precise and stable conjugation of biomolecules, enabling the creation of complex, site-specific constructs. It is an essential tool for researchers and developers in the fields of bioconjugation, antibody-drug conjugate (ADC) development, and advanced therapeutic formulation.

Application

• Antibody-Drug Conjugate (ADC) Linker: A key building block for constructing stable, homogeneous ADCs by linking cytotoxic payloads to antibodies via thiol-maleimide chemistry.
• Protein/Peptide Bioconjugation: Enables site-specific crosslinking of peptides, proteins, or enzymes to other molecules, nanoparticles, or solid surfaces.
• Diagnostic Reagent Synthesis: Used in the development of fluorescent or enzyme-labeled probes and immunoassay components for diagnostic applications.
• Polymer and Biomaterial Functionalization: Facilitates the modification of polymers, hydrogels, and other biomaterials with bioactive ligands to enhance functionality.
• Drug Delivery System Development: Critical for designing targeted drug delivery systems, including liposome and nanoparticle surface modification.
• Research Grade Reagent: Serves as a high-purity intermediate for chemical biology research, proteomics, and novel therapeutic discovery platforms.

Basic Information

Product Name	Bis-Mal-Lysine-Peg4-Tfp Ester
CAS No.	1426164-53-5
Molecular Formula	C41H52F4N4O16
Molecular Weight	916.88 g/mol
Synonyms	Bis-Maleimide-PEG4-Lysine-TFP ester; Lys(Mal-PEG4)2 TFP ester; Nε,Nε-Bis[2-[2-[2-[2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethoxy]ethoxy]ethoxy]acetyl]-L-lysine 2,3,5,6-tetrafluorophenyl ester; BML-PEG4-TFP; Heterobifunctional PEG crosslinker, Mal-PEG4-Lys-PEG4-Mal TFP ester; TFP-PEG4-Lys(Mal-PEG4)2
EINECS	Contact for details

Quality Control

Our Bis-Mal-Lysine-Peg4-Tfp Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and functional group analysis. Certificates of Analysis (COA) detailing all specifications are provided to ensure traceability and batch-to-batch consistency for your critical research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white solid or viscous oil
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.