Description

Maleimide-PEG12-NH is a heterobifunctional polyethylene glycol (PEG) linker featuring a maleimide group for thiol conjugation and a primary amine for further functionalization. This compound is critical for creating stable, site-specific bioconjugates with controlled spacing and enhanced solubility. It is primarily utilized by researchers and manufacturers in biopharmaceutical development, diagnostic assay production, and advanced materials science.

Application

• Antibody-Drug Conjugate (ADC) Linker: For the precise attachment of cytotoxic payloads to monoclonal antibodies via cysteine residues.
• PEGylation Reagent: To modify peptides, proteins, or nanoparticles, improving their pharmacokinetic properties and stability.
• Surface Functionalization: For immobilizing biomolecules onto biosensor chips, microarrays, or other solid supports.
• Crosslinking Agent: In the synthesis of hydrogels or polymer networks with tailored mechanical and biological properties.
• Diagnostic Probe Synthesis: Conjugating fluorescent dyes or other reporter molecules to targeting ligands (e.g., antibodies, peptides).
• Protein/Peptide Labeling: Site-specific modification of cysteine-containing biomolecules for structural or functional studies.

Basic Information

Product Name	Maleimide-PEG12-NH
CAS No.	1426151-00-9
Molecular Formula	C55H102N2O26
Molecular Weight	~1207.4 g/mol
Synonyms	Maleimide-PEG12-Amine; MAL-PEG12-NH2; 3-Maleimidopropanoic acid-PEG12-amine; N-(3-Maleimidopropionyl)-PEG12-amine; Amine-PEG12-Maleimide; α-Amine-ω-maleimide PEG; PEG12-(N-3-maleimidopropionamide); Heterobifunctional PEG linker, Maleimide-NH2
EINECS	Contact for details

Quality Control

Our Maleimide-PEG12-NH is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and mass spectrometry, to ensure it meets the high standards required for research and bioconjugation applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and functional group integrity is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white solid or viscous liquid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Functional Group Purity (Maleimide)	≥ 90%
Water Content (KF)	≤ 1.0%
Molecular Weight (MS)	Conforms

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.