Description

Azido-Peg5-Acid is a heterobifunctional polyethylene glycol (PEG) linker featuring a terminal azide group and a carboxylic acid group. This bifunctionality is critical for creating stable, biocompatible conjugates via click chemistry and amide bond formation, enabling precise molecular assembly. It is an essential building block for researchers and manufacturers in pharmaceutical development, bioconjugation, and advanced materials science, where controlled modification and linkage of biomolecules are required.

Application

• Bioconjugation and ADC Development: Used as a linker to attach cytotoxic drugs, fluorescent dyes, or other payloads to antibodies, proteins, or peptides for targeted therapies and diagnostics.
• PEGylation Reagent: Serves to introduce PEG chains onto drug molecules or surfaces to improve solubility, prolong circulation time, and reduce immunogenicity.
• Click Chemistry Substrate: The terminal azide group readily participates in copper-catalyzed or strain-promoted azide-alkyne cycloaddition (CuAAC/SPAAC) for efficient, site-specific labeling and crosslinking.
• Polymer and Hydrogel Synthesis: Acts as a functional monomer or crosslinker in the creation of smart biomaterials, drug delivery scaffolds, and hydrogels with tailored properties.
• Surface Functionalization: Utilized to modify nanoparticles, biosensors, and diagnostic platforms with bioactive ligands or to create non-fouling surfaces.
• Proteomics Research: Employed in chemical proteomics for labeling and enriching specific proteins or studying protein-protein interactions.

Basic Information

Product Name	Azido-Peg5-Acid
CAS No.	1425973-16-5
Molecular Formula	C17H31N3O8
Molecular Weight	405.44 g/mol
Synonyms	15-Azido-4,7,10,13-tetraoxapentadecanoic acid; Azido-PEG5-COOH; N3-PEG5-Acid; 2-[2-[2-[2-[2-(2-Azidoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]acetic acid; Azido tetraethylene glycol acetic acid; Azido-OEG4-acetic acid; PEG4-Azide-Acid; Azido-PEG4-CH2COOH
EINECS	Contact for details

Quality Control

Our Azido-Peg5-Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistent performance for research and commercial applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This compound is hygroscopic (moisture-sensitive); desiccate for long-term storage. Allow the sealed container to reach room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or oil
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Acid Value (Titration)	Conforms to theoretical

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.