Description

Propargyl-Peg6-Tos is a specialized bifunctional polyethylene glycol (PEG) linker featuring a propargyl group and a tosylate leaving group, separated by a hexaethylene glycol spacer. This compound is a critical reagent in bioconjugation and click chemistry, enabling the efficient, site-specific modification of biomolecules, polymers, and surfaces under mild, aqueous conditions. It is essential for researchers and manufacturers in pharmaceutical development, proteomics, and advanced materials science who require high-purity, reliable linkers for constructing complex molecular architectures.

Application

• Bioconjugation and Antibody-Drug Conjugate (ADC) Development: Used as a heterobifunctional crosslinker to attach cytotoxic payloads, fluorescent dyes, or other functional molecules to antibodies, proteins, or peptides via copper-catalyzed azide-alkyne cycloaddition (CuAAC).
• Polymer and Dendrimer Functionalization: Serves as a versatile building block for introducing alkyne handles into PEG-based polymers, hydrogels, and dendrimers for subsequent modular assembly.
• Surface Modification and Immobilization: Facilitates the covalent attachment of biomolecules or functional layers to sensor chips, nanoparticles, and other material surfaces for diagnostics and biosensing applications.
• Proteomics and Chemical Biology Tool Development: Enables the synthesis of activity-based probes and affinity tags for studying protein function, interactions, and localization within cells.
• Nucleic Acid Labeling: Employed in the synthesis of modified oligonucleotides for detection, tracking, and therapeutic purposes.
• Precision Drug Delivery Systems: A key component in the design of smart drug delivery carriers, allowing for controlled release and targeted therapy.

Basic Information

Product Name	Propargyl-Peg6-Tos
CAS No.	1422023-55-9
Molecular Formula	C26H42O11S
Molecular Weight	562.68 g/mol
Synonyms	Propargyl-PEG6-OTs; 2,5,8,11,14,17-Hexaoxanonadec-19-yn-1-yl 4-methylbenzenesulfonate; Tosyl-PEG6-propargyl; Propargyl-PEG6-tosylate; Alkyne-PEG6-OTs; 19-Propargyl-3,6,9,12,15,18-hexaoxanonadecyl 4-methylbenzenesulfonate; Propargyl hexaethylene glycol tosylate; N-(Propargyl)-hexaethylene glycol-p-toluenesulfonate
EINECS	Contact for details

Quality Control

Every batch of Propargyl-Peg6-Tos is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, which includes data from HPLC, NMR, and mass spectrometry. Our quality commitment aligns with the standards required for research and cGMP manufacturing applications. Certificates of Analysis (COA) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Allow the sealed vial to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.