Description

Endo-Bcn-Peg4-Acid CAS NO 1421932-54-8 is a high-purity, heterobifunctional polyethylene glycol (PEG) linker featuring an endo-Bicyclo[6.1.0]nonyne (endo-BCN) group and a carboxylic acid terminus. This compound is engineered for efficient, copper-free click chemistry applications, enabling the stable conjugation of biomolecules under mild, physiologically relevant conditions. It is an essential reagent for researchers and manufacturers in bioconjugation, pharmaceutical development, and advanced material science, where precise and biocompatible cross-linking is required.

Application

• Bioconjugation and Antibody-Drug Conjugate (ADC) Development: Site-specific labeling of proteins, antibodies, and peptides for therapeutic and diagnostic applications.
• Proteomics and Biomarker Research: Functionalization of surfaces and nanoparticles for biosensor development and assay platforms.
• Polymer and Material Science: Synthesis of functionalized hydrogels, smart materials, and drug delivery systems via strain-promoted azide-alkyne cycloaddition (SPAAC).
• Chemical Biology Tool Development: Creation of activity-based probes and imaging agents for live-cell labeling and tracking.
• Diagnostic Reagent Formulation: Production of stable, high-affinity conjugates for immunoassays and in vitro diagnostics (IVD).
• Precision Medicine: Facilitating the development of targeted therapies through controlled linker technology.

Basic Information

Product Name	Endo-Bcn-Peg4-Acid
CAS No.	1421932-54-8
Molecular Formula	C24H41NO8
Molecular Weight	471.59 g/mol
Synonyms	endo-BCN-PEG4-acid; (1R,8S,9S)-Bicyclo[6.1.0]non-4-yn-9-ylmethyl (1-oxo-2,5,8,11-tetraoxatetradecan-14-yl)carbamate; 2,5,8,11-Tetraoxatetradecan-14-oic acid, 14-[[(1R,8S,9S)-bicyclo[6.1.0]non-4-yn-9-ylmethoxy]carbonyl]amino]-; BCN-PEG4-COOH; endo-BCN-PEG4-COOH; endo-BCN-PEG4-Acid; Azadibenzocyclooctyne-PEG4-acid (endo isomer)
EINECS	Contact for details

Quality Control

Our Endo-Bcn-Peg4-Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, supporting its use in research and pre-clinical development.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a desiccator before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white solid or viscous oil
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF, acetonitrile, methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.