Description

Npec-Caged-D-Ap5 is a specialized, photolabile caged compound designed for precise, light-triggered release of the neurotransmitter antagonist D-AP5. This matters for researchers requiring high temporal and spatial control in neurobiological studies, particularly in the investigation of glutamate receptor function and synaptic plasticity. It is an essential tool for advanced neuroscience, cellular biology, and pharmacology research, enabling controlled experiments in live cells and tissues.

Application

• Neuroscience Research: Precise, light-activated antagonism of NMDA receptors to study synaptic transmission, long-term potentiation (LTP), and long-term depression (LTD).
• Cellular Physiology: Spatiotemporally controlled release of D-AP5 in live-cell imaging and electrophysiology experiments.
• Photopharmacology: A key tool for developing and applying light-gated pharmacological agents to probe neural circuits with minimal invasiveness.
• Neuropharmacology Studies: Investigating the role of NMDA receptors in neurological disorders and potential therapeutic pathways.
• Biochemical Assays: Used in in vitro systems to trigger and study glutamate receptor-mediated signaling cascades with precise timing.

Basic Information

Product Name	Npec-Caged-D-Ap5
CAS No.	1416943-27-5
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	1-(2-Nitrophenyl)ethyl-caged D-AP5; NPE-caged D-AP5; Caged D-2-Amino-5-phosphonopentanoic acid; (R)-1-(2-Nitrophenyl)ethyl ester of D-AP5; Photolabile D-AP5; Light-sensitive D-AP5; D-AP5, NPE-caged; D-AP5, 1-(2-Nitrophenyl)ethyl ester
EINECS	Contact for details

Quality Control

Our Npec-Caged-D-Ap5 is produced and handled under strict quality protocols to ensure batch-to-batch consistency and optimal performance in sensitive research applications. Each lot undergoes rigorous analytical testing, including HPLC for purity and identity confirmation. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and stability is provided with every shipment to support your research documentation and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This compound is strictly light-sensitive and must be handled under subdued light or in amber glass to prevent premature uncaging. Allow the vial to equilibrate to room temperature in the dark before opening to minimize condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/UV)	Conforms
Purity (HPLC)	≥95%
Solubility	Soluble in DMSO, aqueous buffer (upon uncaging)
Extinction Coefficient	Contact for details
Uncaging Efficiency	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.