Description

3-Oxa-6-Aza-Bicyclo[3.1.1]Heptane Tosylate is a high-purity, advanced pharmaceutical intermediate characterized by its unique bridged bicyclic structure. This compound is critical for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in the development of central nervous system (CNS) and antiviral therapeutics. It is essential for research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in cutting-edge drug discovery and process chemistry.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of complex drug molecules, especially those targeting neurological disorders.
• Proteolysis Targeting Chimera (PROTAC) Development: Used as a component in the linker or warhead design for targeted protein degradation platforms.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Antiviral Agent Synthesis: Employed in the research and development of novel antiviral compounds.
• Chemical Biology Probes: Utilized in the creation of molecular probes to study enzyme function and biological pathways.
• Process Chemistry & Scale-Up: Supplied for route scouting, optimization, and cGMP manufacturing of clinical trial materials.

Basic Information

Product Name	3-Oxa-6-Aza-Bicyclo[3.1.1]Heptane Tosylate
CAS No.	1414860-36-8
Molecular Formula	C12H15NO4S
Molecular Weight	269.32 g/mol
Synonyms	3-Oxa-6-azabicyclo[3.1.1]heptane p-toluenesulfonate; 6-Aza-3-oxabicyclo[3.1.1]heptane Tosylate; 3-Oxa-6-aza-bicyclo[3.1.1]heptane tosylate salt; 1414860-36-8; Bicyclo[3.1.1]heptane, 3-oxa-6-aza-, tosylate; 6-Tosyl-3-oxa-6-azabicyclo[3.1.1]heptane
EINECS	Contact for details

Quality Control

Our 3-Oxa-6-Aza-Bicyclo[3.1.1]Heptane Tosylate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and KF titration for moisture content, to ensure it meets the stringent requirements for pharmaceutical R&D and production. A detailed Certificate of Analysis (COA) is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) in a desiccator for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.