Description

Verosudil Hydrochloride is a potent and selective Rho-associated coiled-coil containing protein kinase (ROCK) inhibitor, specifically developed for pharmaceutical applications. This high-purity active pharmaceutical ingredient (API) is critical for advancing research and development in targeted therapeutic areas. It is primarily utilized by pharmaceutical manufacturers and research institutions focused on developing novel treatments for ophthalmic and fibrotic conditions.

Application

• Pharmaceutical API: Primary use as the active ingredient in the formulation of finished dosage forms for clinical and commercial use.
• Ophthalmic Drug Development: Key component in the research and production of therapeutics for glaucoma and other conditions affecting ocular fluid dynamics.
• Anti-fibrotic Research: Used in preclinical and clinical studies targeting pathological fibrosis in various organ systems.
• ROCK Pathway Investigation: Serves as a critical reference standard and tool compound in biochemical and cellular assays studying Rho kinase signaling.
• Process Development & Scale-up: Employed in the optimization of synthetic routes and manufacturing processes for commercial production.
• Regulatory Submissions: Supplied as a characterized substance for inclusion in regulatory filings (e.g., DMF, CMC sections) to support drug approval.

Basic Information

Product Name	Verosudil Hydrochloride
CAS No.	1414854-44-6
Molecular Formula	C₂₀H₂₇ClN₄O₃ • HCl
Molecular Weight	435.37 g/mol
Synonyms	Netarsudil Hydrochloride; AR-13324 Hydrochloride; (S)-4-(3-Amino-1-(isoquinolin-6-ylamino)-1-oxopropan-2-yl)benzyl 2,4-dimethyl-1,4-dihydro-2H-pyrido[2,3-b][1,4]oxazine-3-carboxylate hydrochloride; ROCK Inhibitor AR-13324 HCl; AR 13324 Hydrochloride
EINECS	Contact for details

Quality Control

Our Verosudil Hydrochloride is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC for purity, chiral purity determination, residual solvent analysis, and identification by spectroscopic methods, to ensure it meets stringent pharmaceutical-grade specifications. Certificates of Analysis (COA) with full traceability are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.5%
Chiral Purity (HPLC)	≥ 99.0%
Related Substances (HPLC)	Individual impurity: ≤ 0.5% Total impurities: ≤ 1.5%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.