Description

1H-1,4,7-Triazonine-1,4,7-Triacetic Acid, α1-[3-[(2,5-Dioxo-1-Pyrrolidinyl)Oxy]-3-Oxopropyl]Hexahydro- is a high-purity, functionalized macrocyclic chelating agent designed for advanced bioconjugation and radiopharmaceutical applications. This compound is critical for creating stable, site-specific linkages between targeting vectors and diagnostic or therapeutic payloads. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and medical imaging sectors for developing next-generation radiopharmaceuticals and targeted drug delivery systems.

Application

• Radiopharmaceutical Precursor: Acts as a bifunctional chelator for labeling peptides, antibodies, and other biomolecules with radioisotopes (e.g., Gallium-68, Lutetium-177) for PET imaging and targeted radionuclide therapy.
• Bioconjugation Linker: The activated NHS ester moiety enables efficient and stable amide bond formation with primary amines on proteins, antibodies, or nanoparticles for creating targeted conjugates.
• Diagnostic Agent Development: Used in the synthesis of contrast agents and probes for molecular imaging, enhancing specificity and signal.
• Research Chemical: Serves as a key intermediate in academic and industrial research focused on novel chelation chemistry, drug delivery platforms, and theranostic agents.
• Metal Ion Scavenging: The triaza macrocyclic structure provides high affinity for specific metal ions, useful in purification processes or environmental testing.

Basic Information

Product Name	1H-1,4,7-Triazonine-1,4,7-Triacetic Acid, α1-[3-[(2,5-Dioxo-1-Pyrrolidinyl)Oxy]-3-Oxopropyl]Hexahydro-
CAS No.	1407166-70-4
Molecular Formula	C17H24N4O9
Molecular Weight	428.40 g/mol
Synonyms	NODAGA-NHS ester; 2,2',2''-(1,4,7-Triazonane-1,4,7-triyl)triacetic acid, 1-(2,5-dioxo-1-pyrrolidinyl) ester; 1,4,7-Triazacyclononane-1,4,7-triacetic acid, NHS ester; NODAGA-NHS; NODAGA active ester; 2,2',2''-(1,4,7-Triazacyclononane-1,4,7-triyl)triacetic acid, N-hydroxysuccinimide ester; 1,4,7-Triazacyclononane-N,N',N''-triacetic acid, NHS ester; α1-[3-[(2,5-Dioxo-1-pyrrolidinyl)oxy]-3-oxopropyl]hexahydro-1H-1,4,7-triazonine-1,4,7-triacetic acid
EINECS	Contact for details

Quality Control

Our 1H-1,4,7-Triazonine-1,4,7-Triacetic Acid, α1-[3-[(2,5-Dioxo-1-Pyrrolidinyl)Oxy]-3-Oxopropyl]Hexahydro- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C or below. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and reactivity. Allow the sealed vial to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF; Slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.