Description

cis-4-Methylsphingosine CAS NO 1407154-31-7 is a synthetic, high-purity sphingolipid analog, a key intermediate in the study of sphingolipid metabolism and signaling pathways. This compound is of significant value for pharmaceutical and biochemical research, enabling the investigation of cell proliferation, apoptosis, and autophagy. It is primarily needed by research institutions, pharmaceutical R&D departments, and specialty chemical manufacturers focused on developing novel therapeutics for cancer, metabolic disorders, and inflammatory diseases.

Application

• Biochemical Research: A critical tool compound for studying sphingolipid biology, including ceramide synthesis and sphingosine-1-phosphate (S1P) signaling pathways.
• Pharmaceutical R&D: Serves as a key intermediate or reference standard in the development of novel therapeutics targeting cancer, autoimmune diseases, and metabolic syndromes.
• Enzyme Inhibition Studies: Used as a potential inhibitor or substrate analog for enzymes like sphingosine kinases and ceramide synthases in mechanistic studies.
• Cell Signaling & Apoptosis Research: Employed in cell culture models to modulate sphingolipid levels and investigate their role in programmed cell death and cellular stress responses.
• Academic Research: Utilized in universities and research institutes for fundamental studies on lipid metabolism, membrane biology, and signal transduction.
• Reference Standard: Acts as a high-purity analytical standard for method development and quality control in laboratories synthesizing or analyzing sphingolipid derivatives.

Basic Information

Product Name	cis-4-Methylsphingosine
CAS No.	1407154-31-7
Molecular Formula	C19H39NO2
Molecular Weight	313.52 g/mol
Synonyms	(2S,3R,4E)-2-Amino-4-octadecene-1,3-diol, 4-Methyl-; 4-Methyl-D-erythro-sphingosine; 4-Methylsphingosine; (2S,3R,4E)-2-Amino-4-methyloctadec-4-ene-1,3-diol; cis-4-Methyl-D-erythro-sphingosine; 4-Methylsphingosine (cis isomer); Sphingosine, 4-methyl-; 4-Me-Sph
EINECS	Contact for details

Quality Control

Our cis-4-Methylsphingosine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and chiral analysis to ensure stereochemical integrity. Certificates of Analysis (COA) detailing all specifications are provided to ensure compliance with research-grade standards and support your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) due to its hygroscopic and potentially oxidizable nature. For long-term storage, desiccants are recommended. Allow the sealed container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.