Description

(1-Oxyl-2,2,5,5-Tetramethyl-3-Pyrroline-3-Methyl) Methanethiosulfonate-15N is a stable nitroxide radical spin label containing a 15N isotope and a reactive methanethiosulfonate (MTS) group, enabling site-directed spin labeling (SDSL) for advanced electron paramagnetic resonance (EPR) spectroscopy. This compound is critical for studying protein dynamics, conformational changes, and biomolecular interactions with high sensitivity and resolution due to the 15N isotopic enrichment. It is primarily needed by research institutions, pharmaceutical developers, and biotech companies engaged in structural biology and drug discovery.

Application

• Site-Directed Spin Labeling (SDSL) for Electron Paramagnetic Resonance (EPR) spectroscopy of proteins and nucleic acids.
• Investigation of protein folding, dynamics, and conformational changes in solution.
• Mapping membrane protein topology and studying lipid-protein interactions.
• Distance measurements via Double Electron-Electron Resonance (DEER/PELDOR) for structural modeling.
• Studying enzyme mechanisms and active site accessibility.
• Development of biosensors and molecular probes for diagnostic applications.
• Research into aggregation states in neurodegenerative disease-related proteins.
• Use as a reference standard or reagent in analytical method development for spin-labeled compounds.

Basic Information

Product Name	(1-Oxyl-2,2,5,5-Tetramethyl-3-Pyrroline-3-Methyl) Methanethiosulfonate-15N
CAS No.	1404308-02-6
Molecular Formula	C11H2015NNO3S2
Molecular Weight	Contact for details
Synonyms	MTSSL-15N; MTSL-15N; (1-Oxyl-2,2,5,5-tetramethylpyrroline-3-methyl)methanethiosulfonate-15N; 15N-labeled MTSL; 15N-MTSSL; S-(1-Oxyl-2,2,5,5-tetramethyl-3-pyrrolin-3-ylmethyl) methanethiosulfonate-15N; 15N Isotope labeled spin label; 15N-MTS spin label
EINECS	Contact for details

Quality Control

Our (1-Oxyl-2,2,5,5-Tetramethyl-3-Pyrroline-3-Methyl) Methanethiosulfonate-15N is produced under strict quality management protocols to ensure high isotopic purity and chemical integrity, essential for sensitive spectroscopic applications. Each batch is characterized by advanced analytical techniques including NMR, HPLC, and EPR to confirm identity, purity, and spin label functionality. Certificates of Analysis (COA) detailing isotopic enrichment, chemical purity, and performance data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) in a dry, freezer environment. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed container to reach ambient temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	Off-white to pale yellow solid
Identification (IR)	Conforms to structure
Identification (EPR)	Characteristic nitroxide radical signal
Purity (HPLC)	≥ 95%
Isotopic Enrichment (15N)	≥ 98 atom %
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, ethanol, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.