Description

Dspe-Peg-Cooh is a heterobifunctional polyethylene glycol (PEG) derivative featuring a distearoylphosphatidylethanolamine (DSPE) lipid anchor and a terminal carboxylic acid (COOH) group. This amphiphilic structure is engineered to facilitate the creation of stable, biocompatible, and functionalized nanocarriers for advanced delivery systems. It is an essential building block for research and development teams in the pharmaceutical, biotechnology, and advanced materials sectors seeking to enhance drug solubility, circulation time, and targeted delivery.

Application

• Liposome and Lipid Nanoparticle (LNP) Functionalization: Conjugation of targeting ligands (e.g., antibodies, peptides) or drugs to the surface of PEGylated liposomes for active targeting.
• PEGylation of Nanocarriers: Creating stealth coatings on micelles, polymeric nanoparticles, and solid lipid nanoparticles to reduce opsonization and prolong systemic circulation.
• Drug-Delivery Conjugate Synthesis: Acting as a linker to covalently attach therapeutic payloads (e.g., chemotherapeutic agents, siRNA) to lipid-PEG constructs.
• Diagnostic Agent Formulation: Development of contrast agents for imaging (MRI, fluorescence) by attaching diagnostic molecules to the carboxylic acid terminus.
• Surface Modification of Biomaterials: Grafting onto implant surfaces or scaffolds to improve biocompatibility, reduce protein fouling, and enable further biofunctionalization.
• Stabilization of Emulsions and Dispersions: Use as a surfactant or stabilizer in complex colloidal systems for cosmetic and industrial applications.

Basic Information

Product Name	Dspe-Peg-Cooh
CAS No.	1403744-37-5
Molecular Formula	Contact for details
Molecular Weight	Variable (depends on PEG chain length)
Synonyms	1,2-Distearoyl-sn-glycero-3-phosphoethanolamine-N-[carboxy(polyethylene glycol)]; DSPE-PEG-COOH; DSPE-PEG-Carboxylic Acid; DSPE-PEG-Acid; 1,2-Distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-carboxyl]; Phospholipid-PEG-COOH; Lipid-PEG-Carboxyl; PEGylated DSPE carboxylic acid
EINECS	Contact for details

Quality Control

Our Dspe-Peg-Cooh is manufactured under strict quality management protocols. Each batch undergoes rigorous analytical testing to ensure high purity, consistent molecular weight distribution, and functional group integrity. Standard characterization includes NMR, HPLC, and functional group titration. Certificates of Analysis (COA) detailing lot-specific results are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive) and should be allowed to equilibrate to room temperature in a dry environment before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white solid or waxy solid
Identification (NMR)	Conforms to structure
PEG Average Molecular Weight	2000, 3400, 5000 Da (or as requested)
Purity (HPLC)	≥95%
Functional Group (COOH) Content	≥90% of theoretical
Water Content (KF)	≤1.0%
Solvents (Residual)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.