Description

Diquafosol is a synthetic dinucleotide derivative and a potent P2Y2 receptor agonist, representing a significant advancement in targeted therapeutic development. Its primary value lies in its ability to stimulate tear and mucin secretion, making it a critical active pharmaceutical ingredient (API) for addressing severe ocular surface disorders. This compound is essential for pharmaceutical manufacturers and R&D institutions focused on developing innovative treatments for conditions like dry eye disease. Diquafosol CAS NO 1402828-42-5 is supplied under stringent quality control to ensure consistency and efficacy in final drug formulations.

Application

• Primary Active Pharmaceutical Ingredient (API) in ophthalmic solutions for the treatment of dry eye syndrome.
• Key intermediate in advanced pharmaceutical research for P2Y2 receptor-targeted therapies.
• Reference standard for analytical method development and quality control in pharmaceutical laboratories.
• Biochemical research tool for studying purinergic signaling pathways and ocular surface physiology.
• Formulation component in preclinical and clinical trial materials for novel ophthalmic drugs.

Basic Information

Product Name	Diquafosol
CAS No.	1402828-42-5
Molecular Formula	C18H25N6O16P2
Molecular Weight	667.37 g/mol
Synonyms	Diquafosol Tetrasodium; INS365; UR-29257; 5'-O-[Hydroxy(phosphonooxy)phosphoryl]uridine 5'-(P'-→5')-guanosine Tetrasodium Salt; P1-(5'-Uridyl) P4-(5'-guanosyl) Tetraphosphate Tetrasodium Salt; Diquafosol Sodium; Uridine 5'-(tetrahydrogen tetraphosphate) 5'-5'-ester with guanosine, tetrasodium salt
EINECS	Contact for details

Quality Control

Our Diquafosol is manufactured and tested to meet the exacting standards required for pharmaceutical active ingredients. Each batch undergoes comprehensive analytical testing, including HPLC for purity and assay, identification by spectroscopic methods (IR, NMR), and stringent control of residual solvents and impurities. A detailed Certificate of Analysis (COA) is provided, confirming compliance with in-house specifications developed under a quality system aligned with GMP principles.

Storage

Preserve in a tightly closed container, protected from light. Due to its hygroscopic (moisture-sensitive) nature, the container should be stored in a cool, dry place. For long-term stability, store at controlled room temperature (15-25°C) in a desiccated environment. Handle the container with care to prevent moisture ingress after opening.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time conforms to reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 5.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.