Description

(S)-(9H-Fluoren-9-Yl)Methyl Pyrrolidin-3-Ylcarbamate Hydrochloride is a high-purity chiral building block and pharmaceutical intermediate of significant importance in modern synthetic chemistry. Its core value lies in providing a structurally defined, enantiomerically pure scaffold essential for the development of novel active pharmaceutical ingredients (APIs) and fine chemicals. This compound is primarily needed by research institutions and manufacturers in the pharmaceutical, biotechnology, and advanced materials sectors, where precise molecular architecture is critical for function.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new therapeutic agents, particularly for central nervous system (CNS) and metabolic disorder targets.
• Peptidomimetic Chemistry: Serves as a protected pyrrolidine-based amino acid derivative for constructing peptide analogs and mimetics with enhanced stability and bioavailability.
• Asymmetric Synthesis: Utilized as a chiral auxiliary or ligand precursor in catalytic asymmetric reactions to induce stereoselectivity.
• Protease Inhibitor Development: Incorporated into molecular frameworks designed to inhibit specific enzymes like proteases, which are relevant in virology and oncology.
• Chemical Biology Probes: Used in the synthesis of labeled compounds and molecular probes for studying biological pathways and target engagement.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of client-specific molecules under cGMP conditions.

Basic Information

Product Name	(S)-(9H-Fluoren-9-Yl)Methyl Pyrrolidin-3-Ylcarbamate Hydrochloride
CAS No.	1394822-91-3
Molecular Formula	C20H22N2O2·HCl
Molecular Weight	358.86 g/mol (Free base: 322.40 g/mol)
Synonyms	(S)-Fmoc-3-Amino-pyrrolidine Hydrochloride; (S)-N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-pyrrolidinamine Hydrochloride; (S)-N-Fmoc-3-Aminopyrrolidine HCl; (S)-3-Amino-1-[(9H-fluoren-9-ylmethoxy)carbonyl]pyrrolidine Hydrochloride; Fmoc-Pyrrolidin-3-yl-amine Hydrochloride (S-isomer); (S)-1-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)pyrrolidine-3-carboxylic acid (related acid form); (S)-3-Aminopyrrolidine-1-carboxylic acid 9H-fluoren-9-ylmethyl ester hydrochloride
EINECS	Contact for details

Quality Control

Our (S)-(9H-Fluoren-9-Yl)Methyl Pyrrolidin-3-Ylcarbamate Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure compliance with exacting standards for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing identity, purity (HPLC), chiral purity, and related substances is provided with every shipment. We support development with regulatory documentation as required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider desiccated environments.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.