Description

Propargyl-Peg5-Nhs Ester is a heterobifunctional polyethylene glycol (PEG) linker featuring a propargyl group for copper-catalyzed azide-alkyne cycloaddition (CuAAC) click chemistry and an N-hydroxysuccinimide (NHS) ester for efficient amine conjugation. This compound is essential for creating stable, well-defined bioconjugates and functionalized materials with precise control over structure and properties. It is primarily utilized by researchers and manufacturers in the fields of biopharmaceutical development, advanced material science, and diagnostic assay production.

Application

• Bioconjugation and ADC Development: Site-specific conjugation of antibodies, proteins, or peptides with cytotoxic drugs, fluorophores, or other payloads for therapeutic and diagnostic applications.
• PEGylation Reagent: Introduction of a hydrophilic PEG spacer to enhance the solubility, stability, and pharmacokinetic profile of therapeutic biomolecules.
• Surface Functionalization: Modification of nanoparticles, biosensors, microarrays, and other solid supports with bioactive ligands for targeted interactions.
• Polymer and Dendrimer Synthesis: Building block for constructing complex, multi-functional polymeric architectures via stepwise click chemistry.
• Crosslinking Agent: Creating three-dimensional networks or hydrogel matrices for cell culture, drug delivery, and tissue engineering.
• Chemical Probe Synthesis: Fabrication of activity-based probes for studying enzyme function, protein-protein interactions, and cellular pathways.

Basic Information

Product Name	Propargyl-Peg5-Nhs Ester
CAS No.	1393330-40-9
Molecular Formula	C26H43NO12
Molecular Weight	561.62 g/mol
Synonyms	Propargyl-PEG5-NHS ester; Propargyl-PEG5-NHS ester; 5k-PEG4-Propargyl-PEG4-NHS ester (related); Propargyl-PEG5-NHS; NHS-PEG5-Propargyl; N-(3-{2-[2-(2-{2-[2-(2-Prop-2-yn-1-yloxyethoxy)ethoxy]ethoxy}ethoxy)ethoxy]ethyl}carbamoyl)propionyloxy)succinimide; Propargyl-O-(CH2CH2O)5-CH2CH2-NHS ester; Propargyl-PEG5-N-hydroxysuccinimide ester
EINECS	Contact for details

Quality Control

Our Propargyl-Peg5-Nhs Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistent performance. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your research and development documentation.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a dry environment before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid or viscous oil
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF, acetonitrile, dichloromethane

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.