Description

p-Scn-Bn-Oxo-Do3A (CAS NO 1370442-99-1) is a bifunctional chelator derivative, a key intermediate in the synthesis of advanced diagnostic and therapeutic agents. Its core value lies in its ability to form exceptionally stable complexes with rare earth and radiometal ions, such as Gadolinium (Gd³⁺) and Lutetium (Lu³⁺), which is critical for imaging performance and safety. This compound is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors developing next-generation MRI contrast agents and targeted radiopharmaceuticals for oncology and neurology.

Application

• Synthesis of MRI Contrast Agents: Primary building block for creating high-relaxivity, macrocyclic Gd(III)-based contrast agents.
• Radiopharmaceutical Precursor: Key intermediate for chelators used in Positron Emission Tomography (PET) and Single-Photon Emission Computed Tomography (SPECT) imaging, targeting isotopes like 68Ga and 177Lu.
• Bifunctional Chelator (BFC) Development: The p-isothiocyanatobenzyl (p-SCN-Bn) group enables covalent conjugation to antibodies, peptides, or other targeting vectors.
• Research & Development: Used in academic and industrial R&D for studying metal-ligand kinetics, stability, and novel diagnostic/therapeutic conjugates.
• Theragnostic Agent Production: Facilitates the creation of dual-purpose agents for both imaging and targeted radionuclide therapy.

Basic Information

Product Name	p-Scn-Bn-Oxo-Do3A
CAS No.	1370442-99-1
Molecular Formula	C24H33N5O8
Molecular Weight	519.55 g/mol
Synonyms	2,2',2''-(10-(4-Isothiocyanatobenzyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetic acid; 1,4,7-Tris(carboxymethyl)-10-(4-isothiocyanatobenzyl)-1,4,7,10-tetraazacyclododecane; p-SCN-Bn-Oxo-DO3A; 4-Isothiocyanatobenzyl-oxo-DO3A; Oxo-DO3A-tris(t-butyl ester)-p-SCN-Bn precursor; Bifunctional DO3A derivative; p-SCN-Bn-Oxo-DOTA tris(t-butyl ester); Macrocyclic isothiocyanate chelator
EINECS	Contact for details

Quality Control

Our p-Scn-Bn-Oxo-Do3A is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions or a dry inert atmosphere to maintain stability. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.