Description

n-Glycine Globotriaosylsphingosine (D18:1) is a high-purity, synthetic glycosphingolipid derivative, specifically a globotriaosylceramide (Gb3) analog modified with a glycine moiety. This compound is a critical reference standard and research tool for investigating the structure, function, and metabolism of glycosphingolipids, particularly in the context of Fabry disease and related lysosomal storage disorders. It is essential for scientists and quality control laboratories in the pharmaceutical, biotechnology, and diagnostic sectors who require precise molecular tools for assay development, biomarker validation, and metabolic pathway analysis.

Application

• Biomarker Research & Validation: Serves as a primary reference standard for the quantitative analysis of lyso-Gb3 and related metabolites in biological samples, crucial for Fabry disease research and diagnostics.
• Enzyme Activity Assays: Used as a substrate or inhibitor in enzymatic assays to study the activity of α-galactosidase A and other glycosidases involved in sphingolipid metabolism.
• Diagnostic Kit Development: A key component in the development and calibration of immunoassays, mass spectrometry-based kits, and other in vitro diagnostic (IVD) devices for lysosomal storage disorders.
• Cell Biology & Signaling Studies: Employed to study the role of Gb3 and its derivatives in cell membrane structure, lipid raft formation, and intracellular signaling pathways.
• Therapeutic Drug Monitoring: Acts as a calibration standard for monitoring the efficacy of enzyme replacement therapy (ERT) and other novel treatments for Fabry disease.
• Quality Control (QC) in Pharma: Essential for the QC testing of therapeutic enzymes and gene therapies targeting glycosphingolipid disorders, ensuring product potency and specificity.

Basic Information

Product Name	n-Glycine Globotriaosylsphingosine (D18:1)
CAS No.	1360882-59-2
Molecular Formula	C59H108N2O21
Molecular Weight	1181.5 g/mol (approx.)
Synonyms	Lyso-Gb3 Glycine derivative; Globotriaosylsphingosine Glycine adduct; n-Glycyl-Gb3; Gb3-Gly; Deacylated Globotriaosylceramide Glycine conjugate; Fabry disease biomarker analog; α-Galactosyl-(1→4)-β-galactosyl-(1→4)-β-glucosyl-(1↔1)-2-(glycylamino)-4-octadecene-1,3-diol; Glycine-modified lyso-GL-3
EINECS	Contact for details

Quality Control

Every batch of n-Glycine Globotriaosylsphingosine (D18:1) is manufactured under strict quality management systems and undergoes comprehensive analytical characterization to ensure identity, purity, and consistency. Our quality commitment includes rigorous testing via HPLC, MS, and NMR to meet the exacting standards required for research and diagnostic applications. A detailed Certificate of Analysis (COA) providing batch-specific data is supplied with each product.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, keep desiccated. Allow the vial to warm to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95% (Area Percent)
Assay (by HPLC)	≥ 90% (by weight)
Water Content (KF)	≤ 5.0 %
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.