Description

Enalaprilat-D5, Sodium Salt is a high-purity, deuterium-labeled internal standard critical for modern quantitative bioanalytical research. This stable isotope-labeled analog of the active metabolite of the antihypertensive drug Enalapril is essential for ensuring accuracy and precision in mass spectrometry-based assays. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions engaged in pharmacokinetic studies, drug metabolism research, and clinical trial sample analysis.

Application

• Quantitative Bioanalysis: Serves as an internal standard for the precise quantification of Enalaprilat in biological matrices (plasma, serum, urine) using LC-MS/MS and GC-MS.
• Pharmacokinetic/Pharmacodynamic (PK/PD) Studies: Enables accurate measurement of drug concentration-time profiles to determine absorption, distribution, metabolism, and excretion (ADME) parameters.
• Clinical Trial Support: Critical for the robust bioanalytical method development and validation required in Phase I-IV clinical trials for antihypertensive drugs.
• Drug Metabolism Research: Used in in vitro and in vivo studies to investigate metabolic pathways and enzyme kinetics without interference from endogenous compounds.
• Forensic Toxicology: Aids in the confirmatory analysis and quantification of angiotensin-converting enzyme (ACE) inhibitors in forensic casework.
• Quality Control in Manufacturing: Can be employed in analytical methods for monitoring the purity and stability of pharmaceutical formulations containing related compounds.

Basic Information

Product Name	Enalaprilat-D5, Sodium Salt
CAS No.	1356922-29-6
Molecular Formula	C18H19D5N2NaO5
Molecular Weight	377.42 g/mol (approximate)
Synonyms	(2S)-1-[(2S)-2-[[(1S)-1-Carboxy-3-phenylpropyl]amino]propanoyl]pyrrolidine-2-carboxylic-3,3,4,4,5,5-d5 acid, sodium salt; Enalaprilat-d5 sodium; Sodium (S)-1-((S)-2-(((S)-1-carboxy-3-phenylpropyl)amino)propanoyl)pyrrolidine-2-carboxylate-d5; Deuterated Enalaprilat Sodium Salt; MK-422-d5 sodium salt; Enalaprilat (pentadeuterated) sodium salt
EINECS	Contact for details

Quality Control

Our Enalaprilat-D5, Sodium Salt is manufactured under strict quality systems to ensure the high chemical and isotopic purity required for sensitive analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing results for identity, assay, isotopic enrichment, and purity by HPLC. We adhere to relevant industry guidelines for the production of stable isotope-labeled reference materials.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Enrichment	≥98 atom % D
Chemical Purity	≥95.0%
Water Content (KF)	≤2.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.