Description

(S)-Lisinopril-D5 Sodium is a high-purity, isotopically labeled internal standard critical for advanced analytical applications. This deuterated compound is essential for ensuring the accuracy and reliability of quantitative mass spectrometry analyses, particularly in pharmacokinetic and bioequivalence studies. It is primarily required by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical testing facilities engaged in method development and validation for the antihypertensive drug Lisinopril.

Application

• Internal Standard for LC-MS/MS: Used as a deuterated internal standard for the precise quantification of Lisinopril in complex biological matrices such as plasma, serum, and urine.
• Pharmacokinetic & Bioanalytical Research: Enables accurate tracking of drug absorption, distribution, metabolism, and excretion (ADME) profiles in clinical and pre-clinical studies.
• Method Development & Validation: Serves as a critical reference material for developing and validating robust, regulatory-compliant analytical methods (e.g., following FDA, EMA guidelines).
• Drug Impurity & Metabolite Profiling: Aids in the identification and quantification of drug-related impurities and metabolites.
• Quality Control in Pharmaceutical Manufacturing: Supports in-process testing and final product release testing to ensure drug potency and purity.
• Stability-Indicating Assays: Used in studies to determine the stability and shelf-life of pharmaceutical formulations containing Lisinopril.

Basic Information

Product Name	(S)-Lisinopril-D5 Sodium
CAS No.	1356847-28-3
Molecular Formula	C21H26D5N3O5•xNa
Molecular Weight	Contact for details
Synonyms	Lisinopril-d5 Sodium Salt; (2S)-1-[(2S)-6-Amino-2-[[(1S)-1-carboxy-3-phenylpropyl]amino]hexanoyl]pyrrolidine-2-carboxylic Acid-d5 Sodium Salt; N2-[(S)-1-Carboxy-3-phenylpropyl]-L-lysyl-L-proline-d5 Sodium Salt; MK-521-d5 Sodium; Prinivil-d5 Sodium; Zestril-d5 Sodium; Deuterated Lisinopril Sodium Salt
EINECS	Contact for details

Quality Control

Our (S)-Lisinopril-D5 Sodium is manufactured under strict quality systems to ensure the high chemical and isotopic purity required for sensitive analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing parameters such as assay (by HPLC), isotopic enrichment, residual solvents, and identification. We adhere to relevant industry standards for reference materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (MS)	Conforms to expected mass
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 98 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.