Description

17α-Hydroxyprogesterone-2,3,4-13C3 Solution is a stable isotopically labeled analog of the endogenous steroid hormone 17α-Hydroxyprogesterone, specifically enriched with carbon-13 at the 2, 3, and 4 positions. This compound is essential as a high-purity internal standard for the accurate quantification of 17α-Hydroxyprogesterone in complex biological matrices using advanced analytical techniques like LC-MS/MS. It is a critical tool for clinical diagnostics, endocrinology research, and pharmaceutical development, enabling precise measurement of hormone levels for disease diagnosis and therapeutic monitoring.

Application

• LC-MS/MS Internal Standard: Primary use as a quantitative reference standard for the analysis of endogenous 17α-Hydroxyprogesterone in clinical and research settings.
• Clinical Diagnostics: Enables accurate measurement of 17α-Hydroxyprogesterone levels in serum or plasma for diagnosing conditions like congenital adrenal hyperplasia (CAH).
• Endocrinology & Steroid Metabolism Research: Used in metabolic pathway studies, enzyme activity assays, and investigations into steroid hormone biosynthesis and regulation.
• Pharmaceutical R&D: Supports drug development programs targeting steroidogenic pathways, including the development of enzyme inhibitors.
• Forensic Toxicology: Can be employed in analytical methods to detect and confirm the presence of exogenous progestins or related steroids.
• Method Development & Validation: Serves as a critical component in developing, optimizing, and validating robust bioanalytical methods to meet regulatory standards (e.g., FDA, EMA).
• Quality Control in Reference Material Production: Used in the calibration and verification of certified reference materials (CRMs) for clinical assays.

Basic Information

Product Name	17α-Hydroxyprogesterone-2,3,4-13C3 Solution
CAS No.	1356154-92-1
Molecular Formula	C21H3013C3O3
Molecular Weight	~333.5 g/mol (for 13C3 labeled form)
Synonyms	17α-Hydroxyprogesterone-2,3,4-13C3; 17α-Hydroxy-4-pregnene-3,20-dione-2,3,4-13C3; 17α-OHP-13C3; [2,3,4-13C3]-17α-Hydroxyprogesterone; 17α-Hydroxypregn-4-ene-3,20-dione-2,3,4-13C3; Isotopically Labeled 17α-Hydroxyprogesterone; 17α-Hydroxyprogesterone (13C3, 2,3,4); Internal Standard for 17α-OHP
EINECS	Contact for details

Quality Control

Our 17α-Hydroxyprogesterone-2,3,4-13C3 Solution is manufactured and controlled to meet the exacting requirements of analytical and research applications. Each batch undergoes rigorous quality testing, including HPLC for chemical purity, NMR and MS for isotopic enrichment and structural confirmation, and residual solvent analysis. Certificates of Analysis (COA) are provided, detailing batch-specific data on concentration, solvent, isotopic purity (typically >99 atom % 13C), and chemical purity. Our quality system supports compliance with relevant standards for reference materials.

Storage

Preserve in a tightly closed container, protected from light. Store at the recommended temperature as specified on the label or COA, typically between 2°C and 8°C for long-term stability. The solution is prepared in a compatible organic solvent; handle with appropriate precautions in a well-ventilated area. Avoid exposure to strong acids.

Specification

Item	Specification
Appearance	Clear, colorless to pale yellow solution
Concentration	100 µg/mL (or as specified per batch)
Solvent	Acetonitrile, Methanol, or other suitable solvent
Chemical Purity (HPLC)	≥ 98%
Isotopic Purity (Atom % 13C)	≥ 99% at positions 2,3,4
Isotopic Enrichment (MS)	≥ 99% (M+3)
Identification (NMR/MS)	Conforms to structure

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.