Description

2,2,2-Trifluoro-1-(4-Nitrophenyl)Ethyl 4-Methylbenzenesulfonate is a high-value, multi-functional chemical intermediate characterized by its trifluoromethyl and sulfonate ester groups. This compound is essential for introducing fluorinated motifs and activating leaving groups in advanced synthetic pathways, enabling the development of novel materials and bioactive molecules. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of fluorinated active pharmaceutical ingredients (APIs) and drug candidates, leveraging the trifluoromethyl group to modulate metabolic stability and lipophilicity.
• Agrochemical Synthesis: Used in creating advanced herbicides, fungicides, and pesticides where the fluorinated aromatic structure enhances biological activity and environmental persistence.
• Material Science Precursor: Serves as a monomer or cross-linking agent in the development of specialty polymers, liquid crystals, and organic electronic materials.
• Organic Synthesis Reagent: Acts as an activated ester in nucleophilic substitution reactions (SN2) or as a precursor for generating reactive intermediates in palladium-catalyzed cross-coupling reactions.
• Fluorine Chemistry Research: A valuable tool in academic and industrial R&D for studying the effects of fluorine substitution on chemical reactivity and physical properties.
• Dye and Pigment Intermediate: Utilized in the synthesis of specialized fluorinated dyes and pigments for high-performance applications.

Basic Information

Product Name	2,2,2-Trifluoro-1-(4-Nitrophenyl)Ethyl 4-Methylbenzenesulfonate
CAS No.	1356110-41-2
Molecular Formula	C15H12F3NO5S
Molecular Weight	375.32 g/mol
Synonyms	4-Methylbenzenesulfonic Acid 2,2,2-Trifluoro-1-(4-Nitrophenyl)Ethyl Ester; p-Toluenesulfonic Acid 2,2,2-Trifluoro-1-(4-Nitrophenyl)Ethyl Ester; 1-(4-Nitrophenyl)-2,2,2-trifluoroethyl Tosylate; α,α,α-Trifluoro-4-nitrobenzenemethanol Tosylate; 2,2,2-Trifluoro-1-(4-nitrophenyl)ethyl Tosylate; Tosyloxy(4-nitrophenyl)trifluoroethane; (4-Nitrophenyl)(trifluoromethyl)methyl Tosylate
EINECS	Contact for details

Quality Control

Our production of 2,2,2-Trifluoro-1-(4-Nitrophenyl)Ethyl 4-Methylbenzenesulfonate adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC, NMR, and GC-MS, to verify identity, potency, and impurity profiles. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes. We operate under a cGMP-compliant quality system suitable for supporting pharmaceutical and advanced material applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent hydrolysis or degradation. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.