Description

(R)-2-Amino-2-[(5-Fluoresceinyl)Aminocarbonyl]Ethyl Methanethiosulfonate, Trifluoroacetate Salt is a high-purity, bifunctional chemical reagent designed for advanced bioconjugation and labeling applications. Its core value lies in combining a reactive methanethiosulfonate (MTS) group for site-specific thiol coupling with a fluorescein fluorophore for sensitive detection, enabling precise protein and peptide modification. This compound is essential for researchers and developers in pharmaceutical R&D, proteomics, and diagnostic assay development who require reliable, site-directed fluorescent probes.

Application

• Site-Specific Protein Labeling: Covalent attachment of fluorescein to cysteine residues via the methanethiosulfonate (MTS) group for structural and functional studies.
• Fluorescent Probe Synthesis: A key intermediate for creating custom fluorescent sensors and molecular imaging agents.
• Bioconjugation for Diagnostics: Development of fluorescently-labeled antibodies, peptides, and other biomolecules for ELISA, flow cytometry, and lateral flow assays.
• Mechanistic Studies in Biochemistry: Investigating protein-protein interactions, enzyme kinetics, and receptor-ligand binding using fluorescence-based techniques.
• Pharmaceutical Research: Tool compound for drug discovery, particularly in target identification and validation through fluorescence tagging.
• Material Science Functionalization: Surface modification of nanoparticles or polymers with fluorescent tags for bioimaging and sensing applications.

Basic Information

Product Name	(R)-2-Amino-2-[(5-Fluoresceinyl)Aminocarbonyl]Ethyl Methanethiosulfonate, Trifluoroacetate Salt
CAS No.	1356019-48-1
Molecular Formula	C26H21F3N2O9S2
Molecular Weight	626.58 g/mol
Synonyms	5-Fluorescein MTS; Fluorescein-5-MTS; (R)-2-Amino-2-((5-fluoresceinyl)aminocarbonyl)ethyl methanethiosulfonate TFA salt; Fluorescein Maleimide Alternative; MTS-Fluorescein; 5-FAM MTS; Fluorescein-based Methanethiosulfonate Reagent; 5-(and-6)-Fluorescein Methanethiosulfonate (Isomer not specified)
EINECS	Contact for details

Quality Control

Every batch of (R)-2-Amino-2-[(5-Fluoresceinyl)Aminocarbonyl]Ethyl Methanethiosulfonate, Trifluoroacetate Salt is manufactured and tested under strict quality management systems. We guarantee high chemical purity and performance consistency suitable for sensitive research applications. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) with detailed HPLC purity, identity confirmation (NMR/IR/MS), and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This compound is hygroscopic (moisture-sensitive) and light-sensitive. Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake. For long-term storage, keep under an inert atmosphere.

Specification

Item	Specification
Appearance	Orange to red solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.