Description

1-Palmitoyl-2-(Propargylacetyl)-Sn-Glycero-3-Phosphocholine is a synthetic, functionalized phospholipid featuring a propargyl group, making it a valuable click chemistry reagent for bioconjugation and membrane research. This compound is essential for researchers and manufacturers developing advanced lipid-based drug delivery systems, such as liposomes and lipid nanoparticles (LNPs), where precise chemical modification is required. It is primarily utilized in the pharmaceutical, biotechnology, and life science research sectors for applications ranging from targeted therapy development to fundamental studies of cell membrane dynamics and protein-lipid interactions.

Application

• Click Chemistry Reagent: The terminal alkyne (propargyl) group enables efficient, site-specific conjugation with azide-containing molecules via copper-catalyzed azide-alkyne cycloaddition (CuAAC).
• Functionalized Liposome/LNP Synthesis: Used to incorporate targeting ligands, fluorescent probes, or PEG chains onto the surface of lipid nanoparticles for mRNA delivery, cancer therapeutics, and diagnostic imaging.
• Membrane Protein Studies: Serves as a modified lipid anchor for labeling, immobilizing, or studying membrane-associated proteins in model bilayer systems.
• Biomaterial and Biosensor Development: Facilitates the creation of functionalized lipid membranes on sensors or scaffolds for detecting biomolecular interactions.
• Phospholipid Research Standard: Acts as a critical reference material and synthetic intermediate in academic and industrial lipidomics research.

Basic Information

Item	Details
Product Name	1-Palmitoyl-2-(Propargylacetyl)-Sn-Glycero-3-Phosphocholine
CAS No.	1353897-91-2
Molecular Formula	C₂₈H₅₂NO₈P
Molecular Weight	561.69 g/mol
Synonyms	Propargyl-PC; 1-Palmitoyl-2-propargyl-sn-glycero-3-phosphocholine; PC(16:0/Propynyl); 2-Propargyl-PC; Functionalized Phosphatidylcholine; Click Chemistry Phospholipid; Alkyne-functionalized Phospholipid; Propargyl-modified Lecithin
EINECS	Contact for details

Quality Control

Our 1-Palmitoyl-2-(Propargylacetyl)-Sn-Glycero-3-Phosphocholine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for research and pharmaceutical development. A detailed Certificate of Analysis (COA) documenting purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) for long-term stability. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid or waxy solid
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95% (Area %)
Assay	≥ 98% (by NMR)
Solubility	Soluble in chloroform, methanol, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.