Description

Disuccinimidyl Sulfoxide is a specialized heterobifunctional crosslinking reagent designed for the formation of stable amide bonds. This compound is critical for researchers and manufacturers requiring precise and efficient conjugation of biomolecules, such as proteins and peptides, to various surfaces or other molecules. It is an essential tool in the development of diagnostic assays, bioconjugates for therapeutic applications, and advanced materials research. Professionals in pharmaceutical R&D, biotechnology, and life sciences rely on its consistent performance for creating stable, functionalized constructs.

Application

• Bioconjugation and Protein Labeling: Primary application for covalently linking proteins, antibodies, or peptides to enzymes, fluorophores, or solid supports for immunoassays (ELISA, Western blot) and diagnostic kits.
• Antibody-Drug Conjugate (ADC) Development: Used as a linker precursor or reagent in the research and development of targeted cancer therapies.
• Immobilization Chemistry: Functionalization of sensor chips, microarray slides, magnetic beads, and chromatography resins for biosensing and purification platforms.
• Polymer and Biomaterial Modification: Crosslinking agent for modifying hydrogels, polymers, or nanomaterials to introduce bioactive moieties.
• Peptide Synthesis and Modification: Tool for site-specific modification of synthetic peptides during SPPS (Solid-Phase Peptide Synthesis) or in solution.
• Stable Crosslink Formation: Creates hydrolytically stable amide bonds between amine-containing molecules and carboxylate groups under mild aqueous conditions.

Basic Information

Product Name	Disuccinimidyl Sulfoxide
CAS No.	1351828-03-9
Molecular Formula	C12H12N2O7S
Molecular Weight	328.30 g/mol
Synonyms	DSSO; Disuccinimidyl sulfoxide; N,N'-Disuccinimidyl sulfoxide; Sulfinylbis(2,1-ethanediyloxy-2,1-ethanediyl) bis(2,5-dioxo-1-pyrrolidinecarboxylate); Bis(2,5-dioxopyrrolidin-1-yl) sulfoxide-3,3'-dipropanoate; 3,3'-Sulfinylbis(N-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)propanamide); Heterobifunctional crosslinker DSSO; Amine-to-carboxyl crosslinker
EINECS	Contact for details

Quality Control

Every batch of Disuccinimidyl Sulfoxide is manufactured and tested under strict quality management systems. We ensure high purity and lot-to-lot consistency through comprehensive analytical methods including HPLC, NMR, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting purity, identity, and impurity profiles. Our quality commitment supports applications in regulated research and development environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMF, DMSO, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.