Description

Bis-Propargyl-Peg13 CAS NO 1351373-50-6 is a high-purity, heterobifunctional polyethylene glycol (PEG) derivative featuring terminal propargyl groups, designed for advanced bioconjugation and materials science applications. Its core value lies in its role as a versatile linker and spacer, enabling precise, site-specific coupling via copper-catalyzed azide-alkyne cycloaddition (CuAAC) click chemistry. This compound is essential for researchers and manufacturers in pharmaceutical development, biomaterials engineering, and diagnostic reagent formulation who require controlled, stable, and reproducible molecular assembly.

Application

• ADC (Antibody-Drug Conjugate) Linker: Serves as a hydrophilic, functionalizable PEG spacer to connect cytotoxic payloads to monoclonal antibodies, improving solubility and pharmacokinetics.
• PEGylation Reagent: Used for the site-specific modification of peptides, proteins, and oligonucleotides to enhance stability, reduce immunogenicity, and prolong circulation half-life.
• Hydrogel Formation: Acts as a cross-linking agent in the synthesis of biocompatible hydrogels for drug delivery systems and tissue engineering scaffolds.
• Surface Functionalization: Enables the covalent attachment of biomolecules or polymers to nanoparticles, biosensors, and other material surfaces for diagnostic and therapeutic platforms.
• Polymer Chemistry: A key building block for creating functionalized, linear, or branched co-polymers with tailored properties for specialized material applications.
• Bioconjugation Kit Component: Supplied as a critical reagent in kits for labeling and detecting biomolecules in research and clinical diagnostics.

Basic Information

Item	Detail
Product Name	Bis-Propargyl-Peg13
CAS No.	1351373-50-6
Molecular Formula	C34H62O14
Molecular Weight	694.85 g/mol
Synonyms	1,1'-[1,14-Dioxo-3,6,9,12-tetraoxatetradecane-1,14-diyl]bis(2-propyn-1-ol); α,ω-Bis-propargyl PEG13; Propargyl-PEG13-propargyl; Bis-propargyl PEG 600; 3,6,9,12,15,18,21,24,27,30,33,36,39-Tridecaoxahenpentacontane-1,51-diyn-50-ol; 2,5,8,11,14,17,20,23,26,29,32,35,38-Tridecaoxapentacont-49-yne-1,51-diyne; Heterobifunctional PEG Alkyne Linker
EINECS	Contact for details

Quality Control

Our Bis-Propargyl-Peg13 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure compliance with exacting standards for research and cGMP-grade applications. Comprehensive Certificates of Analysis (COA) detailing purity, moisture content, and functional group integrity are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry, cool environment. This product is hygroscopic (moisture-sensitive). For long-term storage under inert atmosphere, consider sealing under argon or nitrogen.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Average Molecular Weight	650 - 740 g/mol
Functional Group Assay	≥ 90%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.