Description

Thiol-Peg7-Acid is a heterobifunctional polyethylene glycol (PEG) derivative featuring a reactive thiol group at one terminus and a carboxylic acid group at the other. This unique structure makes it an essential heterobifunctional linker for creating stable, customizable conjugates in advanced bioconjugation and materials science. It is primarily used by researchers and manufacturers in the pharmaceutical, biotechnology, and diagnostics industries for developing novel therapeutics, targeted drug delivery systems, and functionalized surfaces.

Application

• Bioconjugation and Protein Modification: Used to site-specifically attach drugs, fluorophores, or other molecules to proteins, antibodies, or peptides via the thiol and carboxyl groups.
• PEGylation Reagent: Acts as a linker to introduce PEG chains onto therapeutic molecules, improving solubility, stability, and pharmacokinetics.
• Surface Functionalization: Employed to modify nanoparticles, quantum dots, or biosensor surfaces to introduce specific reactive handles for further coupling.
• Crosslinking Agent: Facilitates the formation of hydrogels or polymer networks through reactions between the thiol and acid functionalities.
• Drug Delivery System Development: A key component in synthesizing smart linker systems for controlled-release drug delivery platforms.
• Diagnostic Assay Development: Used to create stable conjugates for immunoassays, imaging probes, and other diagnostic tools.

Basic Information

Product Name	Thiol-Peg7-Acid
CAS No.	1347750-77-9
Molecular Formula	C17H34O9S
Molecular Weight	414.5 g/mol
Synonyms	HS-PEG7-COOH; α-Thiol-ω-carboxy hepta(ethylene glycol); 2,5,8,11,14,17,20-Heptaoxadocosane-1,22-dithioic acid, 1-thio-; 17-Carboxy-3,6,9,12,15-pentaoxa-17-thiaoctadecane-1-thiol; Thiol-PEG7-propionic acid; SH-PEG7-COOH; 3,6,9,12,15-Pentaoxa-17-thiaoctadecan-1-ol, 17-carboxy-, 1-thio derivative; Mercapto-PEG7-acid
EINECS	Contact for details

Quality Control

Our Thiol-Peg7-Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistent performance. A comprehensive Certificate of Analysis (COA) is provided, detailing specifications for purity, identity, and functional group integrity as verified by techniques such as NMR and HPLC. We support research and GMP-grade requirements with full traceability and documentation.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C under an inert atmosphere (e.g., nitrogen or argon) to prevent oxidation and moisture absorption. Allow the product to equilibrate to room temperature in a desiccator before opening to avoid condensation.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or oil
Identification (NMR)	Complies with structure
Purity (HPLC)	≥ 95%
Thiol Content (Titration)	≥ 90% of theoretical
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.