Description

Thiol-Peg5-Amine is a heterobifunctional polyethylene glycol (PEG) crosslinker featuring a terminal thiol (-SH) and a terminal primary amine (-NH2) group, separated by a pentaethylene glycol spacer. This molecular architecture is critical for creating stable, hydrophilic, and biocompatible conjugates in advanced bioconjugation and materials science. It is an essential building block for researchers and manufacturers in the pharmaceutical, diagnostics, and biomaterials sectors who require precise, site-specific modification of proteins, peptides, surfaces, and nanoparticles.

Application

• Bioconjugation & Protein Modification: Site-specific PEGylation of antibodies, enzymes, and therapeutic proteins to enhance solubility, reduce immunogenicity, and prolong circulation half-life.
• Surface Functionalization: Creating self-assembled monolayers (SAMs) on gold or other metal surfaces for biosensor development, diagnostic chips, and anti-fouling coatings.
• Hydrogel & Biomaterial Synthesis: Serving as a crosslinking agent for synthesizing tunable, biocompatible hydrogels used in drug delivery systems and tissue engineering scaffolds.
• Nanoparticle Conjugation: Functionalizing quantum dots, liposomes, and polymeric nanoparticles for targeted drug delivery and in vivo imaging applications.
• Linker for Solid-Phase Synthesis: Acting as a versatile, cleavable spacer in peptide and oligonucleotide synthesis on solid supports.
• Diagnostic Assay Development: Conjugating detection molecules (e.g., enzymes, fluorophores) to antibodies or other capture agents in ELISA and lateral flow assays.

Basic Information

Product Name	Thiol-Peg5-Amine
CAS No.	1347750-20-2
Molecular Formula	C14H31NO6S
Molecular Weight	341.46 g/mol
Synonyms	1-Amino-3,6,9,12,15-pentaoxa-18-thiaoctadecane; HS-PEG5-NH2; α-Thiol-ω-amino-pentaethylene glycol; 18-Mercapto-3,6,9,12,15-pentaoxaoctadecan-1-amine; Thiol-PEG5-NH2; Amino-PEG5-thiol; PEG5 spacer, thiol and amine terminated; 2,5,8,11,14-Pentaoxa-17-thiaheptadecan-1-amine
EINECS	Contact for details

Quality Control

Our Thiol-Peg5-Amine is produced under strict quality management protocols. Each batch undergoes comprehensive analytical characterization to ensure identity, purity, and functional group integrity. Certificates of Analysis (COA) are provided with every shipment, detailing results from HPLC, NMR, and functional group titration. We support cGMP manufacturing for pharmaceutical applications and can tailor specifications to meet your specific research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at -20°C or below to minimize oxidation and hydrolysis. For long-term storage, desiccate to protect against moisture. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Thiol Content (Titration)	≥ 90% of theoretical
Amine Content (Titration)	≥ 90% of theoretical
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.