Description

Clomiphene-D5 n-Oxide is a deuterated analog of the clomiphene metabolite, specifically designed for use as an internal standard in analytical chemistry. This high-purity compound is critical for ensuring the accuracy and reliability of quantitative analyses, particularly in pharmacokinetic and metabolism studies. It is an essential tool for pharmaceutical R&D laboratories, clinical research organizations, and regulatory testing facilities requiring precise measurement of clomiphene and its metabolites.

Application

• Internal Standard for LC-MS/MS: Primary application as a stable, isotopically-labeled internal standard for the quantification of clomiphene and its metabolites in biological matrices via liquid chromatography-tandem mass spectrometry.
• Pharmaceutical Research & Development: Used in drug metabolism and pharmacokinetics (DMPK) studies to understand the absorption, distribution, metabolism, and excretion (ADME) profile of clomiphene citrate.
• Clinical and Forensic Toxicology: Enables accurate and sensitive detection and quantification of clomiphene in human plasma, serum, or urine for therapeutic drug monitoring or forensic investigations.
• Method Development and Validation: Serves as a critical component in developing, optimizing, and validating robust analytical methods in compliance with regulatory guidelines (e.g., FDA, EMA).
• Quality Control in Manufacturing: Can be utilized in the quality control processes for the manufacturing of clomiphene citrate APIs or finished dosage forms to monitor impurities or degradation products.

Basic Information

Product Name	Clomiphene-D5 n-Oxide
CAS No.	1346606-55-0
Molecular Formula	C26H23D5ClNO
Molecular Weight	407.98 g/mol (for monoisotopic mass)
Synonyms	2-[4-[(Z)-2-Chloro-1,2-diphenylethenyl]phenoxy]-N,N-di(trideuteriomethyl)ethanamine N-Oxide; Clomiphene D5 N-Oxide; Clomiphene-d5 N-Oxide; Deuterated Clomiphene N-Oxide; [2H5]-Clomiphene N-Oxide; (Z)-Clomiphene-D5 N-Oxide; Clomiphene (D5) N-Oxide
EINECS	Contact for details

Quality Control

Our Clomiphene-D5 n-Oxide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including NMR, HPLC, and mass spectrometry, to confirm identity, isotopic purity (D-enrichment), and chemical purity. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting the exact specifications and test results for traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture absorption. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-enrichment)	≥ 98 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.