Description

Clopamide-D6 is a deuterium-labeled analog of the diuretic pharmaceutical compound clopamide, specifically designed for use as an internal standard in analytical chemistry. This high-purity stable isotope-labeled compound is essential for ensuring the accuracy and reliability of quantitative mass spectrometry (MS) and liquid chromatography-mass spectrometry (LC-MS) analyses. It is primarily required by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical testing facilities engaged in drug metabolism and pharmacokinetics (DMPK) studies, bioanalytical method development, and clinical research.

Application

• Internal Standard for Quantitative LC-MS/MS: Critical for accurate quantification of clopamide in complex biological matrices such as plasma, serum, and urine.
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Used to track the absorption, distribution, metabolism, and excretion (ADME) of the parent drug.
• Bioanalytical Method Development and Validation: Serves as a reference standard to establish precise, sensitive, and reproducible analytical methods.
• Clinical Research and Therapeutic Drug Monitoring (TDM): Enables precise measurement of drug concentration in patient samples for efficacy and safety studies.
• Pharmaceutical Impurity Profiling and Degradation Studies: Aids in the identification and quantification of related substances.
• Forensic and Toxicology Analysis: Used in confirmatory testing for the presence of clopamide in forensic samples.

Basic Information

Product Name	Clopamide-D6
CAS No.	1346602-07-0
Molecular Formula	C14H14D6ClN2O3S
Molecular Weight	~349.85 g/mol
Synonyms	4-Chloro-N-(2,6-dimethyl-1,1-d2-piperidinyl)-3-sulfamoylbenzamide-d4; 3-(Aminosulfonyl)-4-chloro-N-(2,6-dimethylpiperidino)benzamide-d6; Clopamide (hexadeuterated); Clopamide D6; Clopamide-d6 Internal Standard; [2H6]-Clopamide
EINECS	Contact for details

Quality Control

Our Clopamide-D6 is manufactured under strict quality control protocols to ensure the highest isotopic purity and chemical purity required for sensitive analytical applications. Each batch is characterized by advanced spectroscopic and chromatographic techniques, including NMR, HPLC, and MS. A comprehensive Certificate of Analysis (COA) detailing isotopic enrichment (typically ≥98% D), chemical purity (≥98%), and analytical data is provided to guarantee traceability and batch-to-batch consistency for your regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98 atom % D
Chemical Purity (by HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.