Description

6,10-Dihydroxy Buspirone-D8 is a deuterium-labeled analog of a key buspirone metabolite, designed for advanced analytical applications. This high-purity reference standard is critical for ensuring the accuracy and reliability of quantitative mass spectrometry and pharmacokinetic studies. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical service providers specializing in drug metabolism and bioanalytical method development.

Application

• Internal Standard for LC-MS/MS: Serves as a stable isotope-labeled internal standard for the precise quantification of 6,10-dihydroxy buspirone and related metabolites in complex biological matrices like plasma, serum, and urine.
• Pharmacokinetic (PK) and Bioavailability Studies: Enables accurate tracking of metabolite formation and elimination rates in preclinical and clinical studies, supporting drug development and regulatory submissions.
• Drug Metabolism and Disposition (DMPK) Research: Used to elucidate metabolic pathways, study enzyme kinetics, and investigate potential drug-drug interactions involving buspirone.
• Bioanalytical Method Development and Validation: Essential for developing, optimizing, and validating robust, sensitive, and specific HPLC-MS/MS assays in compliance with GLP and FDA/EMA guidelines.
• Forensic and Clinical Toxicology: Supports accurate measurement in forensic analysis or therapeutic drug monitoring programs to ensure patient safety and compliance.

Basic Information

Product Name	6,10-Dihydroxy Buspirone-D8
CAS No.	1346599-17-4
Molecular Formula	C21H23D8N5O4
Molecular Weight	~ 401.53 g/mol
Synonyms	6,10-Dihydroxybuspirone-D8; 6-Hydroxybuspirone-D8 (10-hydroxy); 8-[4-[4-(2-Pyrimidinyl)-1-piperazinyl]butyl]-8-azaspiro[4.5]decane-7,9-dione-6,10-diol-D8; Deuterated 6,10-Dihydroxy Buspirone; Buspirone Metabolite (6,10-diol) Deuterated Standard; 6,10-DiOH-Buspirone-D8; 6,10-Dihydroxy-8-[4-[4-(pyrimidin-2-yl)piperazin-1-yl]butyl]-8-azaspiro[4.5]decane-7,9-dione-D8
EINECS	Contact for details

Quality Control

Every batch of 6,10-Dihydroxy Buspirone-D8 is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure identity, purity, and isotopic enrichment meet the stringent requirements for reference standards. Our quality assurance protocols are designed to support GLP-compliant research. A comprehensive Certificate of Analysis (COA) detailing batch-specific results for assay, isotopic purity, and related substances is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. This compound is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to maintain stability and purity. For long-term storage, consider desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98.0 atom % D
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.