Description

3-Hydroxy Mepivacaine-D3 is a deuterium-labeled analog of the primary metabolite of the local anesthetic mepivacaine. This stable isotope-labeled compound is of critical importance for use as an internal standard in quantitative bioanalytical methods, ensuring the highest accuracy and reliability in pharmacokinetic and metabolic studies. It is an essential tool for pharmaceutical research and development laboratories, clinical research organizations (CROs), and forensic toxicology units that require precise measurement of mepivacaine and its metabolites in biological matrices.

Application

• Internal Standard for LC-MS/MS: Primary application as a quantitative reference standard in liquid chromatography-tandem mass spectrometry (LC-MS/MS) assays for mepivacaine and its metabolites in plasma, serum, and urine.
• Pharmacokinetic & Metabolism Studies: Enables accurate tracking of drug absorption, distribution, metabolism, and excretion (ADME) for mepivacaine in preclinical and clinical research.
• Forensic & Clinical Toxicology: Used in analytical methods for the precise determination of mepivacaine levels in post-mortem or overdose cases, supporting forensic investigations and therapeutic drug monitoring.
• Drug Development & Regulatory Submissions: Supports method validation and data integrity for regulatory filings (e.g., with the FDA, EMA) requiring robust bioanalytical data.
• Reference Material for Metabolite Identification: Serves as a confirmed reference standard for identifying and characterizing the 3-hydroxy metabolite pathway of mepivacaine.

Basic Information

Item	Detail
Product Name	3-Hydroxy Mepivacaine-D3
CAS No.	1346597-79-2
Molecular Formula	C15H19D3N2O2
Molecular Weight	265.38 g/mol (for monoisotopic)
Synonyms	1-Methyl-2',6'-pipecoloxylidide-3-ol-D3; (±)-3-Hydroxymepivacaine-D3; 3-Hydroxy-1-methyl-2',6'-pipecoloxylidide-D3; Mepivacaine 3-hydroxy metabolite-D3; DL-3-Hydroxymepivacaine-D3; 3-OH-Mepivacaine-D3; Mepivacaine-d3 metabolite
EINECS	Contact for details

Quality Control

Every batch of 3-Hydroxy Mepivacaine-D3 is manufactured and analyzed under strict quality management systems. We guarantee high chemical and isotopic purity, confirmed by advanced spectroscopic and chromatographic techniques including NMR, HPLC, and mass spectrometry. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing batch-specific results for identity, purity (HPLC assay), isotopic enrichment, and residual solvents. Our quality commitment ensures the material meets the exacting standards required for sensitive analytical applications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This product is hygroscopic (moisture-sensitive). Keep the container tightly sealed in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D3)	≥ 98.0 atom % D
Chemical Purity	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.