Description

Acid-Peg5-Nhs Ester CAS NO 1343476-41-4 is a heterobifunctional polyethylene glycol (PEG) crosslinker featuring a carboxylic acid group and an N-hydroxysuccinimide (NHS) ester. This compound is critical for creating stable, biocompatible conjugates in aqueous environments, enabling precise and efficient bioconjugation strategies. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and diagnostics industries for protein modification, peptide synthesis, and the development of antibody-drug conjugates (ADCs) and other advanced therapeutics.

Application

• Bioconjugation and Protein Modification: Used to covalently link proteins, peptides, or antibodies to other molecules, surfaces, or nanoparticles via its NHS ester and carboxylic acid groups.
• Antibody-Drug Conjugate (ADC) Development: Serves as a key linker component, connecting cytotoxic payloads to monoclonal antibodies while providing a hydrophilic PEG spacer to improve solubility and pharmacokinetics.
• PEGylation Reagent: Functions as an activated PEG derivative to introduce PEG chains onto biomolecules, enhancing their stability, solubility, and circulation half-life.
• Surface Functionalization: Employed to modify materials and sensor surfaces with carboxylic acid groups for subsequent immobilization of biomolecules in diagnostic assays and biosensors.
• Crosslinking Agent: Facilitates the formation of hydrogels or crosslinked polymer networks for drug delivery systems and tissue engineering scaffolds.
• Diagnostic Reagent Synthesis: Used in the preparation of labeled probes and reagents for immunoassays and molecular imaging.

Basic Information

Product Name	Acid-Peg5-Nhs Ester
CAS No.	1343476-41-4
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	5-Azidopentanoic acid N-hydroxysuccinimide ester; NHS-PEG5-COOH; α-Carboxy-ω-NHS ester PEG; N-(5-Azidopentyl)-2,5-dioxopyrrolidine-1-carboxamide; Carboxylic Acid-PEG5-NHS Ester; HOOC-PEG5-NHS; NHS-PEG5-Acid; PEG-based heterobifunctional crosslinker
EINECS	Contact for details

Quality Control

Our Acid-Peg5-Nhs Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity assessment and NMR for structural confirmation, to ensure it meets the high standards required for research and biopharmaceutical applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and functional group activity is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive) and the NHS ester group is susceptible to hydrolysis. Allow the vial to equilibrate to room temperature in a dry environment before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid or viscous oil
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Functional Group Activity	≥ 90% (by titration or assay)
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMF, DMSO, acetonitrile; partially soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.