Description

n-[6-(2,5-Dioxo-2,5-Dihydro-1H-Pyrrol-1-Yl)Hexanoyl]-L-Valyl-L-Alanine is a specialized, high-purity peptide derivative featuring a maleimide functional group, making it a critical intermediate for bioconjugation and linker chemistry. This compound is engineered to provide reliable and site-specific coupling to thiol-containing molecules, such as cysteine residues in proteins or other biomolecules. It is essential for researchers and manufacturers in the fields of biopharmaceutical development, diagnostic assay production, and advanced drug delivery systems who require precise and stable covalent linkages.

Application

• Antibody-Drug Conjugate (ADC) Linker-Payload Synthesis: Serves as a key building block for constructing cleavable or non-cleavable linkers that connect cytotoxic drugs to monoclonal antibodies.
• Protein and Peptide Labeling: Used for the site-specific conjugation of fluorophores, enzymes, or other probes to proteins for imaging, detection, and diagnostic applications.
• Surface Functionalization: Enables the immobilization of biomolecules onto nanoparticles, biosensors, or chromatography resins via thiol-maleimide chemistry.
• Polymer-Biomolecule Hybrids: Facilitates the creation of smart polymer-drug or polymer-protein conjugates for controlled release and targeted therapies.
• Cross-linking Reagent: Acts as a heterobifunctional cross-linker to create stable bridges between different biomolecular entities.
• Research Grade Biochemical Tools: Provides a reliable reagent for academic and industrial research in chemical biology and bioconjugation methodology development.

Basic Information

Product Name	n-[6-(2,5-Dioxo-2,5-Dihydro-1H-Pyrrol-1-Yl)Hexanoyl]-L-Valyl-L-Alanine
CAS No.	1342211-31-7
Molecular Formula	C19H28N4O7
Molecular Weight	424.45 g/mol
Synonyms	Maleimide-Val-Ala-OH; Maleimidocaproyl-Val-Alanine; MC-Val-Ala; 6-Maleimidocaproyl-L-valyl-L-alanine; L-Alanine, N-[6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-; Val-Ala Maleimide; N-ε-Maleimidocaproyl-L-valyl-L-alanine; Maleimide-PEGn-Val-Ala (core structure)
EINECS	Contact for details

Quality Control

Our production of this high-value biochemical intermediate adheres to stringent quality protocols. Every batch is characterized using advanced analytical techniques including HPLC (for purity and identity), Mass Spectrometry (MS), and NMR to ensure structural integrity and consistency. We provide comprehensive Certificates of Analysis (COA) detailing purity, assay, and impurity profiles, supporting compliance with cGMP guidelines for pharmaceutical intermediate manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Assay	≥ 98.0% (on anhydrous basis)
Water Content (KF)	≤ 2.0%
Single Unknown Impurity	≤ 1.0%
Total Impurities	≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.