Description

1H-1,4,7-Triazonine-1,4,7-Triacetic Acid, Hexahydro-, 1-(2,5-Dioxo-1-Pyrrolidinyl) Ester is a specialized heterocyclic organic compound featuring a triazonine backbone functionalized with acetic acid and a reactive N-hydroxysuccinimide (NHS) ester group. This molecular architecture makes it a valuable bifunctional linker and coupling agent, particularly in advanced bioconjugation and pharmaceutical synthesis. It is primarily utilized by researchers and manufacturers in pharmaceutical development, diagnostic reagent production, and advanced material science for creating stable amide bonds under mild conditions.

Application

• Bioconjugation and Protein Labeling: As an amine-reactive NHS ester, it is used to crosslink biomolecules (e.g., antibodies, peptides, enzymes) with other proteins, fluorescent dyes, or solid supports for diagnostic assays and therapeutic applications.
• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of complex drug candidates, particularly those requiring a stable, water-soluble linker or a chelating moiety.
• Contrast Agent Development: Used in the research and production of gadolinium-based MRI contrast agents, where its triacetic acid groups act as a potent chelator for metal ions.
• Polymer and Material Functionalization: Enables the surface modification of polymers, nanoparticles, and other materials by introducing reactive amine-binding sites or chelating functionalities.
• Diagnostic Kit Manufacturing: Employed in the development of enzyme-linked immunosorbent assays (ELISA), lateral flow tests, and other immunoassays that require stable antibody-enzyme conjugates.
• Research Chemical: A critical reagent in academic and industrial R&D for studying molecular interactions, developing new synthetic methodologies, and creating novel biomaterials.

Basic Information

Product Name	1H-1,4,7-Triazonine-1,4,7-Triacetic Acid, Hexahydro-, 1-(2,5-Dioxo-1-Pyrrolidinyl) Ester
CAS No.	1338231-09-6
Molecular Formula	C14H20N4O8
Molecular Weight	372.33 g/mol
Synonyms	1,4,7-Triazacyclononane-1,4,7-triacetic acid, 1-(N-succinimidyl) ester; NOTA-NHS ester; 1,4,7-Triazacyclononane-N,N',N''-triacetic acid NHS ester; 2,5-Dioxopyrrolidin-1-yl 2,2',2''-(1,4,7-triazonane-1,4,7-triyl)triacetate; Hexahydro-1H-1,4,7-triazonine-1,4,7-triacetic acid, 1-(2,5-dioxo-1-pyrrolidinyl) ester; NOTA tris(NHS ester); TACN-NHS ester
EINECS	Contact for details

Quality Control

Our production of 1H-1,4,7-Triazonine-1,4,7-Triacetic Acid, Hexahydro-, 1-(2,5-Dioxo-1-Pyrrolidinyl) Ester adheres to stringent quality protocols to ensure batch-to-batch consistency and reliability for critical applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and mass spectrometry for identity verification. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all relevant specifications. We support cGMP compliance for pharmaceutical applications and can tailor quality systems to meet specific customer or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at temperatures between -20°C to -10°C for long-term stability. This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Allow the sealed container to equilibrate to room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.