Description

6-[n-(6-Maleimidocaproyl)]Caproic Acid Nhs is a heterobifunctional crosslinking reagent featuring an amine-reactive N-hydroxysuccinimide (NHS) ester and a thiol-reactive maleimide group, separated by a flexible 12-atom spacer arm. This compound matters for its ability to create stable, site-specific conjugates between proteins, peptides, antibodies, and other biomolecules, facilitating advanced research and diagnostic assay development. It is primarily needed by researchers and manufacturers in bioconjugation, antibody-drug conjugate (ADC) development, and diagnostic kit production, where precise and stable covalent linkages are critical.

Application

• Antibody-Drug Conjugate (ADC) Linker: For the site-specific conjugation of cytotoxic payloads to monoclonal antibodies via cysteine residues.
• Protein-Protein/Peptide Conjugation: Enables the crosslinking of different biomolecules for creating novel protein complexes, vaccines, or research tools.
• Surface Immobilization: Functionalizing gold surfaces, chips, or nanoparticles with proteins or peptides for biosensor and microarray development.
• Diagnostic Reagent Manufacturing: Used in the production of enzyme-labeled antibodies and other detection conjugates for ELISA and lateral flow assays.
• Polymer Modification: Introducing reactive maleimide groups onto polymers or hydrogels for subsequent bioconjugation in biomaterial science.
• Stable Mass Tag Labeling: For covalent attachment of labels to proteins in mass spectrometry-based proteomics workflows.

Basic Information

Product Name	6-[n-(6-Maleimidocaproyl)]Caproic Acid Nhs
CAS No.	1337538-62-1
Molecular Formula	C20H28N2O8
Molecular Weight	424.45 g/mol
Synonyms	6-Maleimidohexanoic Acid N-Hydroxysuccinimide Ester; Maleimidocaproyl-NHS; MC-NHS; 6-((6-Maleimidocaproyl)oxy)-2,5-dioxopyrrolidin-1-yl hexanoate; N-(6-Maleimidocaproyloxy)succinimide; SMCC NHS Ester analog; NHS-PEG6-Maleimide (approximate); Heterobifunctional Crosslinker with NHS and Maleimide
EINECS	Contact for details

Quality Control

Our 6-[n-(6-Maleimidocaproyl)]Caproic Acid Nhs is manufactured under strict quality protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive bioconjugation applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and functional performance. We adhere to relevant GMP and ISO 9001 guidelines for the production of research-grade biochemicals.

Storage

Preserve in a tightly closed container, protected from light. Store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Solubility	Soluble in DMF, DMSO, acetonitrile
Water Content (KF)	≤ 1.0%
Functional Test (Conjugation)	Pass

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.