Description

Eravacycline (Dihydrochloride) CAS NO 1334714-66-7 is a novel, fully synthetic fluorocycline antibiotic belonging to the tetracycline class. It matters for its potent activity against a broad spectrum of multidrug-resistant Gram-positive and Gram-negative pathogens, including those resistant to other tetracyclines. This product is essential for pharmaceutical R&D, reference standard preparation, and the development of next-generation antibacterial therapies targeting serious infections.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for quality control and analytical method development in antibiotic manufacturing.
• Antibacterial Research & Development: Serves as a key active pharmaceutical ingredient (API) in preclinical and clinical studies for novel antibiotic formulations.
• Microbiological Studies: Employed in in-vitro assays to determine minimum inhibitory concentrations (MICs) and study mechanisms of action against resistant bacterial strains.
• Hospital & Clinical Laboratory Use: Potential use in specialized susceptibility testing for difficult-to-treat infections caused by carbapenem-resistant Enterobacteriaceae (CRE) and Acinetobacter baumannii.
• Academic Research: Utilized in university and institutional labs for fundamental research on tetracycline-class antibiotics and bacterial resistance.

Basic Information

Item	Detail
Product Name	Eravacycline (Dihydrochloride)
CAS No.	1334714-66-7
Molecular Formula	C27H31FN4O8 · 2HCl
Molecular Weight	627.47 g/mol (Free base: 554.56)
Synonyms	Eravacycline Dihydrochloride; TP-434; TP 434; (4S,4aS,5aR,12aS)-9-Fluoro-4,7-bis(dimethylamino)-3,10,12,12a-tetrahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide Dihydrochloride; 7-Fluoro-9-pyrrolidinoacetamido-6-demethyl-6-deoxytetracycline Dihydrochloride; Xerava (Brand Name API)
EINECS	Contact for details

Quality Control

Our Eravacycline Dihydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and MS, and stringent control of related substances and residual solvents. A Certificate of Analysis (COA) detailing all specifications and test results is provided to ensure compliance with pharmaceutical research and reference standard requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	Yellow to orange-yellow solid
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0% (on anhydrous basis)
Water Content (KF)	≤ 5.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%; Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.