Description

n-Cbz-L-2-Amino-2-Cyclohexyl-Ethanol is a protected amino alcohol derivative, serving as a crucial chiral building block in advanced organic synthesis. Its value lies in providing a stereochemically defined scaffold for constructing complex molecules, particularly in pharmaceutical research and development. This compound is essential for medicinal chemists and process development scientists working on peptide mimetics, protease inhibitors, and other bioactive compounds requiring a rigid, cyclohexyl-based chiral center.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the development of new chemical entities (NCEs), especially in antiviral and anticancer drug discovery programs.
• Peptidomimetic Synthesis: Used to incorporate a constrained, hydrophobic amino acid surrogate into peptide backbones to enhance metabolic stability and binding affinity.
• Asymmetric Catalysis Ligand Precursor: Serves as a starting material for synthesizing chiral ligands and organocatalysts used in enantioselective transformations.
• Protecting Group Strategy: The Cbz (carboxybenzyl) group allows for orthogonal deprotection in multi-step synthetic sequences, common in complex natural product synthesis.
• Chemical Biology Probes: Utilized in the construction of molecular probes and tools for studying enzyme mechanisms and protein-protein interactions.

Basic Information

Product Name	n-Cbz-L-2-Amino-2-Cyclohexyl-Ethanol
CAS No.	1334324-63-8
Molecular Formula	C₁₆H₂₃NO₃
Molecular Weight	277.36 g/mol
Synonyms	N-Carboxybenzyl-L-2-amino-2-cyclohexylethanol; N-Cbz-L-2-Amino-2-cyclohexylethanol; (1S)-2-[[(Benzyloxy)carbonyl]amino]-2-cyclohexyl-1-ethanol; N-[(Benzyloxy)carbonyl]-L-2-amino-2-cyclohexylethanol; Cbz-L-Amino-2-cyclohexylethanol; (S)-2-((Benzyloxycarbonyl)amino)-2-cyclohexylethanol; Z-L-2-Amino-2-cyclohexylethanol
EINECS	Contact for details

Quality Control

Our n-Cbz-L-2-Amino-2-Cyclohexyl-Ethanol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the exacting standards required for research and development applications. Certificates of Analysis (COA) with detailed chromatographic data (HPLC, GC) are provided to guarantee consistent quality, identity, and purity for your critical synthetic steps.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture uptake. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.