Description

Methoxytrityl-n-Peg8-Acid CAS NO 1334177-98-8 is a high-purity, heterobifunctional polyethylene glycol (PEG) derivative featuring a methoxytrityl (MMT) protecting group and a terminal carboxylic acid. This compound is essential for the controlled synthesis and bioconjugation of peptides, oligonucleotides, and other biomolecules, offering precise linker functionality and solubility enhancement. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and diagnostic sectors for developing advanced therapeutics and research reagents.

Application

• Solid-Phase Peptide Synthesis (SPPS): Serves as a versatile linker or spacer arm for the controlled assembly of peptide chains, leveraging the acid-labile MMT protecting group for selective deprotection.
• Oligonucleotide Synthesis: Used as a modifier to introduce hydrophilic PEG spacers into oligonucleotides, improving solubility and altering pharmacokinetic properties.
• Bioconjugation and Protein Modification: The terminal carboxylic acid group enables covalent attachment to amines via standard coupling chemistry, facilitating the PEGylation of proteins, antibodies, or small molecules.
• Drug Delivery System Development: Incorporated into the design of prodrugs, antibody-drug conjugates (ADCs), and nanoparticle formulations to enhance solubility, stability, and targeting.
• Biomaterial and Hydrogel Fabrication: Acts as a functional cross-linking agent or modifier to create PEG-based hydrogels with tailored chemical and physical properties for tissue engineering and controlled release.
• Diagnostic Reagent Preparation: Employed in the synthesis of labeled probes and assay components where a defined, hydrophilic spacer is required between a detection moiety and a binding molecule.

Basic Information

Product Name	Methoxytrityl-n-Peg8-Acid
CAS No.	1334177-98-8
Molecular Formula	C58H80O13
Molecular Weight	985.24 g/mol
Synonyms	MMT-PEG8-COOH; 4-Monomethoxytrityl-amino-PEG8-acid; α-(4-Monomethoxytritylamino)-ω-carboxyocta(ethylene glycol); Monomethoxytrityl-PEG8-acid; MMT-NH-PEG8-COOH; (MMT-N-amido-PEG8)-acetic acid; PEG8-MMT-acid; Heptaethylene glycol monomethoxytrityl ether acetic acid
EINECS	Contact for details

Quality Control

Our Methoxytrityl-n-Peg8-Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure compliance with exacting standards for research and pharmaceutical applications. Comprehensive Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive); desiccate upon opening and seal tightly under an inert atmosphere such as argon or nitrogen for long-term storage to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid or viscous oil
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Assay	≥ 90% (by weight)
Water Content (KF)	≤ 1.0%
Solvent Residues (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.